摘要
目的 探讨血清脂肪酸结合蛋白4（FABP4）、成纤维细胞生长因子21（FGF21）及摄食抑制因子1（Nesfatin-1）与妊娠糖尿病（GDM）患者胰岛素抵抗的关系.方法 选取60例GDM患者为观察组,60例健康孕妇为对照组,比较两组血脂、血糖、胰岛素抵抗指标及FABP4、FGF21、Nesfatin-1水平的差异,分析FABP4、FGF21、Nesfatin-1与胰岛素抵抗的相关性.结果 观察组FABP4[（27.39±3.58）μg/L比（18.41±3.62）μg/L]、FGF21[（193.29±17.31）ng/L比（102.83±18.33）ng/L]、Nesfatin-1[（2.49±0.61）μg/L比（1.97±0.56）μg/L]水平均显著高于对照组,差异均有统计学意义（t=13.662、27.728、4.862,均P〈0.05）.Pearson秩相关分析显示：FABP4、FGF21、Nesfatin-1与胰岛素抵抗指标（HOMA-IR、HOMA-β、ISI、ΔI30/ΔG30）中的HOMA-IR呈正相关（r=0.489、0.368、0.968,均P〈0.05）,与HOMA-β、ISI呈负相关（r=-0.567、-0.389、-0.722、-0.497、-0.674、-0.957,均P〈0.05）.结论 GDM患者体内存在明显的糖脂代谢紊乱及胰岛素抵抗,且患者血清FABP4、FGF21、Nesfatin-1水平显著升高,并与胰岛素抵抗相关.
Objective To investigate the relationship between insulin resistance and FABP4,FGF21 and Nesfatin-1 in patients with gestational diabetes mellitus （ GDM） . Methods 60 patients with GDM were selected as the observation group,60 healthy pregnant women served as control group. The indicators of blood lipid,blood sugar, insulin resistance and the levels of FABP4, FGF21 and Nesfatin -1 were compared between the two groups. The correlation of FABP4,FGF21,Nesfatin -1 and insulin resistance was analyzed. Results The FABP4 [（27. 39 ± 3.58）μg/Lvs.（18.41±3.62）μg/L],FGF21[（193.29±17.31）ng/Lvs.（102.83±18.33）ng/L],Nesfatin-1 [（2. 49 ± 0. 61）μg/L vs. （1. 97 ± 0. 56）μg/L] levels of the observation group were significantly higher than those of the control group,the differences were statistically significant （t =13. 662,27. 728,4. 862,all P〈0. 05）. Pearson correlation analysis showed that FABP4,FGF21,Nesfatin-1 （r=0. 489,0. 368,0. 968,all P〈0. 05） were positively associated with HOMAIR,and were negatively correlated with HOMA beta,ISI （ r= -0. 567,-0. 389,-0. 722,-0. 497,-0. 674,-0. 957,all P〈0. 05）. Conclusion There is obvious disorder of glucose and lipid metabolism and insulin resistance in patients with GDM. The serum levels of FABP4,FGF21 and Nesfatin-1 are significantly increased,and are related to insulin resistance.
出处
《中国基层医药》
CAS
2017年第22期3390-3393,共4页
Chinese Journal of Primary Medicine and Pharmacy
