摘要
目的探讨血清人绒毛促性腺激素（13-HCG）、孕酮和雌二醇（E2）水平在非正常妊娠早期诊断中的应用价值。方法选取非正常妊娠患者（53例）和正常妊娠孕妇（30例），采用全自动微粒子化学发光检测β-HCG、E2和孕酮的表达水平。结果入院当天，正常妊娠孕妇和非正常妊娠孕妇孕酮表达水平未随孕周增加而有显著变化（t=10．42，P〈0．05）；β-HCG表达水平则随着孕周增大而呈递增趋势，差异有统计学意义（t=7．98，P〈0．05）；对照组和观察组患者体内E2表达水平随孕周而呈较小上升趋势，差异无统计学意义（t=0．43，P〉0．05）；而且，独立于孕周因素，非正常妊娠组和正常妊娠组孕酮、E2和β-HCG表达水平均显著低于对照组，差异均有统计学意义（均P〈0．05）。保守治疗非正常妊娠患者成功率为73．81％。B．HCG表达水平在治疗成功和治疗失败人群中表达水平差异无统计学意义（t=0．382，P〉0．05），而孕酮和E：表达水平在治疗成功患者血清中表达水平远远高于失败患者，差异均有统计学意义（t=9．431、6．792，均P〈0．05）；当孕酮阈值设定为12ng／mL时，其评价指标意义最好，可作为评估患者是否适合保守治疗方案的重要指标。结论血中E2、孕酮和β-HCG表达水平检测可作为临床诊断和治疗非正常妊娠孕妇的重要检测指标。
Objective To explore the value of serum human ehorionic gonadotropin （ β - HCG） and progesterone （P） levels in the early diagnosis for abnormal pregnancy. Methods 53 cases with abnormal pregnancy and 30 normal pregnancy women were enrolled from Sep. 2009 to Dec. 2014 in our hospital. The automated chemilumi- nescent microparticle was used to detect the levels of β - HCG and P in serum, then analyzed the results. Results The expression of P was not associated with gestational weeks both in the normal and abnormal pregnancy patients on the day of admission （t = 10.42 ,P 〈 0. 05） ,while the expression of β-HCG was increased with gestational weeks, and the difference was statistically significant （ t = 7.98, P 〈 0.05 ）. The level of E2 in both two groups had slight elevated with the gestationlal factors （ t = 0.43, P 〉 0.05 ）. Despite of gestational factors, the levels of E2/β - HCG and P in abnormal pregnancy group were lower than those in normal pregnancy group, the differences were statistically significant （ all P 〈 0.05 ）. Analysis of the effective rate of conservative treatment for abnormal pregnancy patients, and it showed that success rate was 73.81%. Further analysis showed that the expression of β - HCG was not different in the success group and failure group （t =0. 382,P 〉0.05） ,while the levels of P and E2 were much higher in success group thfin those in failure group with significant difference （t = 9.431,6.792 ,all P 〈 0.05 ）. It showed that 12 ng/mL was the best one with perfect diagnosis value, and it could be used as an important index to evaluate the suitability of conservative treatment for abnormal pregnancy patients. Conclusion The levels of E2/β - HCG and P in serum can be used as important predictors in clinical diagnosis of abnormal pregnancy patients.
作者
吴柏群
边文辉
Wu Baiqun Bian Wenhui(Department of Gynecology, the Maternal and Child Health Hospital of Cixi, Cixi, Zhejiang 315300, China)
出处
《中国基层医药》
CAS
2017年第21期3286-3289,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
人绒毛促性腺激素
孕酮
雌二醇
Human chorionic gonadotrop
Progesterone
Estradiol 2
