摘要
炎症小体在炎症相关疾病的发生发展中发挥重要作用,其中NLRP3炎症小体能够被多种病原相关分子模式(pathogen-associated molecular patterns,PAMPs)和损伤相关分子模式(damage-associated molecular patterns,DAMPs)激活,进而活化caspase-1,释放成熟形式的IL-1β和IL-18,引起机体的炎症反应,并参与多种疾病的发生发展,包括2型糖尿病、痛风、动脉粥样硬化、神经退行性疾病、肿瘤、炎症性肠病等。因此,研究NLRP3炎症小体的作用机制不仅有助于加深对炎症性疾病发生发展的认识,也为寻找此类疾病的潜在治疗靶点提供了新的思路。就NLRP3炎症小体在炎症相关疾病中的研究进展作一综述。
Inflammasomes play an important role in the initial and progressive process among various inflammation-related diseases.The NLRP3 inflammasome is vital in the innate immune system.It could recognize series of pathogen-associated molecular patterns（PAMPs） and damage-associated molecular patterns（DAMPs） and be activated.Activated NLRP3 inflammasome stimulates caspase-1 activation that triggers maturation and secretion of pro-inflammatory cytokines,including interleukin-1β and interleukin-18.A number of recent landmark studies revealed that inflammation-related diseases such as type 2 diabetes,gout,atherosclerosis,neurodegenerative diseases,cancer,inflammatory bowel disease（IBD） are closely related with NLRP3 inflammasome.Thus,study on the NLRP3 inflammasome in inflammation-related diseases not only expands our understanding on these diseases,but also provides a potential therapeutic target for these diseases.Here we review the recent studies on the pathological contributions of NLRP3 inflammasome in various inflammation-related diseases.
作者
蒋丹露
刘阳阳
孙如愚
陈晟
王迪
JIANG Dan-Lu LIU Yang-Yang SUN Ru-Yu CHEN Sheng WAND Di(Research Group of Immune Metabolism, Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China)
出处
《生命科学》
CSCD
2017年第9期898-907,共10页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31670926)
国家自然科学基金优秀青年基金项目(31522020)
