摘要
CD4^+CD25^+FOXP3^+调节性T细胞(Treg)负责维持体内免疫稳态和免疫耐受,转录因子FOXP3对于其发育分化及生理功能至关重要。FOXP3功能在转录、翻译和翻译后修饰等多个层次被精细调控。Treg在肿瘤微环境中聚集而介导肿瘤的免疫逃逸,减少微环境中的Treg细胞数量并降低其活性,有助于促进机体的抗肿瘤免疫反应。深入研究不同组织及不同炎症微环境下Treg功能调节机制及其细胞特异性表面标志物,将为肿瘤免疫治疗提供新思路和新策略。
Regulatory T（Treg） cells play a key role in the maintenance of immune homeostasis and tolerance and the transcription factor FOXP3 is essential for its development and differentiation.The function of FOXP3 is delicately regulated at multiply levels,including transcriptional,translational and post-translational modification.Regulatory T cells accumulate in tumor microenvironment and play a role in promoting tumor escape.The antitumor response could be greatly improved by elimination and activity inhibition of Tregs at the tumor microenvironment.Understanding the mechanism of functional regulation and identifying special markers of Tregs will stimulate new ideas and directions for anti-tumor immunotherapy.
作者
赵彬彬
伊刚
王帅威
李斌
ZHAO Bin-Bin YI Gang WANG Shuai-Wei LI Bin(Key Laboratory of Molecular Virology ＆ Immunology, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China Shanghai Key Laboratory of Bio-energy Crops, College of Life Science, Shanghai University, Shanghai 200444, China Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China)
出处
《生命科学》
CSCD
2017年第9期833-844,共12页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金杰青项目(31525008)
国家自然科学基金重点项目(81330072)
国家自然科学基金面上项目(31370863)
