摘要
以2,3-二氯亚苄基乙酰乙酸甲酯和3-氨基巴豆酸氰乙酯为起始原料,经过环化、水解和酯交换反应得到丁酸氯维地平,工艺具有原料易得、反应步骤少、收率高等特点。
2,3-dichlorobenzylideneacetoacetate and 3-amino crotonic acid cyanoethyl ester make Clevidipine butyrate by cyclization,hydrolysis and transesterification reaction.In the process raw materials are easy to obtain,the route is less and the yield is high.
出处
《山东化工》
CAS
2017年第19期31-31,34,共2页
Shandong Chemical Industry
关键词
丁酸氯维地平
高血压
合成路线
clevidipine butyrate
hypertension
synthetic route
