摘要
目的探究高危人类乳头瘤病毒(HPV)感染对妇女阴道乳酸杆菌的影响。方法选取2014年1月-2016年1月于医院接受治疗的64例高危HPV感染患者为观察组,另选取同期体检阴道微生态正常者64例作为对照组;采集两组妇女阴道分泌物,检测两组阴道乳酸杆菌种类及含有的HPV-DNA载量;对两组妇女阴道内乳酸杆菌数目、种类及所占阴道细菌总数比值进行对比,分析计算乳酸杆菌数、阴道清洁度与HPV-DNA的关系。结果观察组妇女阴道乳酸菌计数及乳酸杆菌所占阴道细菌总数的比值分别为(104.21±70.14)个/HP、(0.74±0.02)均显著低于对照组(196.25±75.36)个/HP、(0.89±0.07)(P<0.05);两组妇女阴道乳酸菌数与HPV-DNA载量,经Spearman相关性分析,两者呈负相关(P<0.05);两组阴道清洁度与HPV-DNA载量,经Spearman相关性分析,两者呈正相关(P<0.05);两组妇女阴道惰性乳酸杆菌、加氏乳酸杆菌、卷曲乳酸杆菌数目,差异均有统计学意义(P均<0.05)。结论高危HPV感染可能与阴道乳酸杆菌减少及菌群失调密切相关,增加乳酸杆菌含量并提高阴道清洁度可减小高危人类乳头瘤病毒感染率。
OBJECTIVE To investigate the effect of high-risk human papillomavirus（HPV）infections on vaginal Lactobacilli in women.METHODS Sixty-four patients with high-risk HPV infections who were treated in our hospital from Jan.2014 to Jan.2016 were selected as observation group,and 64 patients with normal vaginal microecology were selected as control group.Vaginal secretions of the two groups of women were collected.The types of vaginal Lactobacilli and the load of HPV-DNA of the two groups were detected.The number,type and total number of vaginal bacteria were compared between the two groups,and the relationship between the number of Lactobacilli and vaginal cleanliness and HPV-DNA was analyzed.RESULTS The vaginal Lactobacilli count and the ratio of Lactobacilli to total bacterial count in the vagina of observation group were（104.21±70.14）/HP and0.74±0.02,which were lower than（196.25±75.36）/HP and 0.89±0.07 of control group,and the difference was significant（P〈0.05）.The Spearman correlation analysis showed a negative correlation between the number of vaginal Lactobacilli and the load of HPV-DNA of the two groups（P〈0.05）,and a npositive correlation between the vaginal cleanliness and the load of HPV-DNA of the two groups（P〈0.05）.The vaginal Lactobacilliinert,Lactobacilli and Lactobacilli of the two groups of women had significant differences（P 0.05）.CONCLUSION High-risk HPV infection may be closely related to the reduction of vaginal Lactobacilli and the imbalance of bacteria,and increasing the content of Lactobacilli and improving the cleanliness of the vagina can reduce the risk of HPV infection.
作者
古萍
姜静
郑建英
孙莉雅
张梅
GU Ping JIANG Jing ZHENG Jian-ying SUN Li-ya ZHANG Mei(Yibin Second People＇s Hospital, Yibin, Sichuan 644000, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第20期4747-4750,共4页
Chinese Journal of Nosocomiology
