摘要
目的 研究中老年女性2型糖尿病患者膀胱功能障碍与糖尿病病程的相关性,探讨膀胱过度活动症症状评分（OABSS）在早期糖尿病膀胱功能障碍筛查中的应用价值.方法 选取2013年10月至2016年10月于我院就诊的年龄≥40岁的1 157例女性2型糖尿病患者进行问卷调查.年龄40～ 88岁,平均60.2岁;体重指数16.7 ～ 36.1 kg/m2,平均24.6 kg/m2;糖化血红蛋白（HbA1 c）4％ ～ 13％,平均7.8％;糖尿病病程16 ～46年,平均10.4年.403例口服药物治疗,239例接受胰岛素治疗,515例二者联合应用.731例合并高血压病,164例有心脏病史,436例伴周围神经病变,295例有脑血管病史,721例有高脂血症.调查内容包括患者基本信息、既往史、现病史、OABSS和生活质量（QOL）评分等.采用t检验、单因素方差分析以及多重线性回归分析法对调查结果进行分析.结果 1 157例患者的OABSS为2.45±1.38,其中糖尿病病程＜10年者OABSS为1.94±1.23;糖尿病病程10～ 20年者OABSS为3.24±1.45;糖尿病病程＞20年者OABSS为4.00±1.72,不同糖尿病病程的OABSS比较差异有统计学意义,随着病程增加,OABSS增加（F=48.419,P＜0.001）.不同HbA1c水平、年龄、是否并发周围神经病变的OABSS差异有统计学意义（均P＜0.05）.不同BMI分级、治疗方式的OABSS差异无统计学意义（均P＞0.05）;糖尿病患者是否合并有高血压病、心脏病史、高血脂症、脑血管病史的OABSS差异无统计学意义（均P＞0.05）.将以上有意义的因素进行多因素分析,结果表明糖尿病病程、HbA1c水平、年龄、合并周围神经病变是影响OABSS的因素,其中病程的标准偏回归系数最高,为0.366,对OABSS的影响最大.OABSS与QOL评分呈正相关（r=0.434,P＜0.001）.结论 中老年女性2型糖尿病患者中膀胱功能障碍相关症状的OABSS与病程、是否并发周围神经病变、HbA1c及年龄相关,其中病程对OABSS影响最为显著.OABSS可作为早期评估糖尿病�
Objective To analyze the overactive bladder symptom score （OABSS） in evaluating bladder dysfunction in the different stages among type 2 diabetes mellitus patients,and to explore the value of bladder hyperactivity symptom score in screening early diabetic bladder dysfunction.Methods A total of 1 157 patients with type 2 diabetes mellitus,aged 40-88 yearswith mean age of 60.2 years,were enrolled from October 2013 to October 2016.The survey included the patients＆#39; characteristics,past history,current history,OABSS and quality of life （QOL） index scores.T test,single factor analysis of variance and multiple regression analysis are used to analyze the results.Results As many as 1 157 were qualified for final statistical analysis.OABSS is 1.94 ± 1.23 in group with diabetes duration 〈 10 years,3.24 ± 1.45in group with diabetes duration 10-20 years,and 4.00 ± 1.72 in group with diabetes duration 〉 20 years.The differences of OABSS in the different duration of diabetes was statistically significant.As diabetic duration increased,OABSS value increased （F =48.419,P 〈 0.001）.The difference of OABSS in the different HbA1c level,age and concurrent peripheral neuropathy was statistically significant.There was no significant difference of OABSS in the different BMI and distinct therapies.There was no significant difference of OABSS in diabetes with hypertension and without hypertension,with cardiopathy and without cardiopathy,with cerebrovascular disease （CVD） and without CVD,with hyperhpemia and without hyperlipemia.The significant factors were used to make multivariate analysis.The results showed that the duration of diabetes,HbA1 c level,age,peripheral neuropathy were still statistically significant.Standardized partial regression coefficient of diabetic duration was 0.366.OABSS was positively correlated with QOL score （r =0.434,P 〈 0.001）.Conclusions The related symptoms in OABSS with diabetic bladder dysfunction is correlated with the duration of diabetes,HbA1c level,age,concurrent perip
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2017年第10期782-785,共4页
Chinese Journal of Urology
基金
国家自然科学基金（81370861）
山西省国际科技合作项目（2014081052）
