摘要
现代激光光动力治疗仪难以大面积清除肿瘤细胞。设计了一种LED阵列肿瘤光热光动力热治疗仪。采用温度传感、集成电路、风冷和纳米光散射效应,将串、并联的LED阵列光源转变为均匀的3D冷光源。该治疗仪具有液晶显示、温度控制系统,功率可调,照度可调,照射时间可调。该治疗仪波长在400~2 000nm之间,通过更换不同的灯珠来改变激发波长。实验表明该仪器能大面积、快速杀死或清除肿瘤细胞。此仪器与光敏剂在可见-近红外波段靶向吸收的纳米材料配合使用,对皮肤或浅表性肿瘤能发挥协同治疗作用。
Laser photodynamic therapy equipment is difficult to remove the large area of tumor cells in clinic.A new method for rapidly removing tumor in larger area is developed.The control system that employs temperature sensor,integrated circuits,air cooling technique and nanoparticle light-scattering effect,turns the light of series connection and parallel LED assays into 3D cold light source uniformly.The liquid crystal display,irradiation temperature,power,time,and brightness are adjustable by digital combined logic circuit.The emission wavelengths of the therapeutic device range from 400 nm to 2 000 nm with different lamp bead.Initial experiments demonstrated that the device could rapidly kill and eliminate tumor cells in large area.The therapeutic apparatus can synergistically treat cutaneous tumor or superficial cancer with photosensitizer and targeted absorbing nanomaterial at visible light to near infrared wave band.
作者
聂国朝
俸小平
赖昌生
潘心红
沈雪莲
王敏
黄彩惠
伍春华
黄方婷
孙力军
NIE Guo-chao FENG Xiao-ping LAI Chang-sheng PAN Xin-hong SHEN Xue-lian WANG Min HUANG Cai-hui WU Chun-hua HUANG Fang-ring SUN Li-jun(School of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China 0neology Department, Yulin Red Cross Hospital, Yulin 537000, China Nanning Kelun New Technical Co. , Ltd, Nanning 537001, China Center of Nano Biomedicine, Yulin Normal University, Yulin 537000, China Clinical Medical College, Three Gorges University, Yichang, 443003, China School o{ Stomatology and medicine, Foshan University, Foshan 52800, China Shenzhen Institutes of Advanced Technology, Chinese Academy of Science Shenzhem 518055 China)
出处
《光学与光电技术》
2017年第5期80-84,共5页
Optics & Optoelectronic Technology
基金
国家自然科学基金(81660508)
广西科技攻重点研究计划(AB16380153)
南宁市科攻关计划(20153331
20151032)
国家级大学创新创业训练计划(201710606007
201710607008)
广西自治区大学创新创业训练计划(201710606077)资助项目
关键词
浅表性肿瘤
光动力治疗
光热治疗
3D-LED冷光源
协同治疗效应
superficial tumor
photodynamic therapy
hyperthermia
3D-LED cold light source
synergistic therapeutic effect
