摘要
目的探讨他汀类药物引发肝损伤的特点。方法回顾性分析26例他汀类药物致肝损伤患者年龄、性别、肝病史、临床表现、实验室指标、服药情况及治疗等。结果 26例患者女性19例,男性7例;临床表现有纳差、乏力、尿黄等;临床分型以肝细胞损伤型为主;涉及药品5种,以辛伐他汀、阿托伐他汀、瑞舒伐他汀为主。结论他汀类药物引起肝损伤,临床表现形式多样,但转归较好。
Objective To investigate the characteristics of patients with statins-induced liver injury.MethodsTwenty-six patients with statins-induced liver injury were enrolled,and age,sex,liver disease history,clinical manifestations,laboratory index,drugs,treatments,etc.were retrospectively analyzed.Results Among all the patients,19 were female and 7 were male.Clinical manifestations included poor appetite,fatigue,yellow urine and so on.Hepatocellular type was the predominant type in these cases.Five kinds of drugs were involved,mainly including simvastatin,atorvastatin,and rosuvastatin.Conclusion Patients with statins-induced liver injury had various clinical manifestations with comparatively good prognosis.
出处
《肝脏》
2017年第10期885-887,903,共4页
Chinese Hepatology
