摘要
目的探讨发病前24h服用抗血小板药物对急性缺血性卒中患者静脉溶栓治疗近期疗效及远期预后的影响。方法选取陕西省第四人民医院2014年11月—2016年10月收治的接受阿替普酶静脉溶栓的急性缺血性卒中282例,根据患者发病前24h有无服用抗血小板药物分为观察组(使用抗血小板药物)及对照组(未使用抗血小板药物)。观察2组近期疗效、远期预后及安全性。结果观察组静脉溶栓治疗后近期疗效优于对照组(P<0.05)。2组远期疗效及病死率比较差异无统计学意义(P>0.05)。结论发病前24h服用抗血小板药物能提高急性缺血性卒中患者静脉溶栓的近期疗效,对远期预后及安全性无明显影响。
Objective To investigate effects of taking antiplatelet drugs at 24 h before onset on short-term effica-cy and long-term prognosis of intravenous thrombolysis of patients with acute ischemic stroke. Methods A total of 282 patients with acute ischemic stroke, who were treated with Alteplase intravenous thrombolysis during November 2014 and October 2016, were divided into observation group （ taking antiplatelet drugs） and control group （ without taking anti-platelet drugs） . Short-term efficacy, long-term prognosis and safety were observed in two groups. Results The short-term efficacy in observation group was better than that in control group （P〈0. 05）. There were no significant difference in long-term efficacy and fatality rate （P〉0. 05）. Conclusion Taking antiplatelet drugs at 24 h before onset can im-prove short-term efficacy, but it has no obvious effects on long-term prognosis and safety of patients with acute ischemic stroke.
出处
《解放军医药杂志》
CAS
2017年第10期102-105,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
陕西省科技攻关计划项目(QS061-C33-21)
关键词
血小板聚集抑制剂
缺氧缺血
脑
卒中
静脉溶栓
预后
Platelet aggregation inhibitors
Hypoxia-ischemia
brain
Stroke
Intravenous thrombolysis
Prog-nosis
