摘要
目的探讨左炔诺孕酮宫内释放系统治疗子宫内膜增生伴多囊卵巢综合征(polycystic ovary syndrome,PCOS)的疗效和安全性。方法选择2015年6个月-2016年6月惠州市中心人民医院收治的30例子宫内膜增生伴PCOS患者为研究对象。给予患者单纯左炔诺孕酮宫内释放系统治疗,并比较分析治疗前和治疗6个月后患者子宫内膜厚度及代谢相关指标变化。结果接受左炔诺孕酮宫内释放系统治疗6个月后,各型子宫内膜增生患者的子宫内膜厚度均显著降低(P<0.001)。总胆固醇和低密度脂蛋白胆固醇水平治疗后显著低于治疗前(P<0.05)。雄激素水平在治疗后显著升高(P<0.05)。结论应用左炔诺孕酮宫内释放系统治疗子宫内膜增生伴PCOS能够显著降低子宫内膜厚度,并改善患者血脂代谢,但存在增加患者高雄激素血症的风险。
Objective To explore the curative effect and safety of levonorgestrel-releasing intrauterine system （LNG-IUS） in treat- ment of endometrial hyperplasia complicated with polycystic ovary syndrome （PCOS） . Methods Thirty patients with endometrial hyperpla- sia complicated with PCOS treated in the hospital from June 2015 to June 2016 were selected, then they were treated by LNG-IUS. Endome- trial thicknesses and changes of metabolism-related indexes before and after treatment were compared and analyzed. Results After treated by LNG-IUS for 6 months, endometrial thicknesses of patients with difference types of endometrial hyperplasia decreased significantly （ P〈 0. 001 ） . The levels of serum total cholesterol and low-density lipoprotein cholesterin after treatment were statistically significantly lower than those before treatment （P〈0. 05） . The level of androgen after treatment was statistically significantly higher than that before treatment （P〈0. 05） . Conclusion LNG-IUS can significantly reduce endometrial thickness and improve blood lipid metabolism of patients with en- dometrial hyperplasia complicated with PCOS, but it may increase the risk of hyperandrogenism.
作者
唐莉菲
肖勇
吴佳佳
TANG Li-Fei XIAO Yong WU Jia-Jia(Department of Gynecology, Central People＇s Hospital of Huizhou City, Huizhou, Guangdong 516000, China)
出处
《中国妇幼保健》
CAS
2017年第20期5127-5129,共3页
Maternal and Child Health Care of China
基金
惠州市科技计划项目(20160804)
关键词
左炔诺孕酮宫内释放系统
子宫内膜增生
多囊卵巢综合征
疗效
安全性
Levonorgestrel-releasing intrauterine system
Endometrial hyperplasia
Polycystic ovary syndrome
Curative effect
Security
