摘要
由于恶性肿瘤极度威胁到人类的健康,抗癌药物的研发成为了当今医学界的重要课题。中医药作为我国独有的治疗方法,其抗癌性被广泛研究。经研究发现,单味以及复方形式的抗肿瘤中药,根据作用机制,可被分成9类:(1)使得肿瘤细胞失去多药耐药性(MDR);(2)细胞毒作用抑制癌症;(3)提高免疫细胞活性,刺激免疫细胞生成细胞因子;(4)抑制新血管的形成;(5)激活凋亡家族,抑制抑凋亡家族;(6)影响细胞内外信号传递;(7)刺激癌细胞进一步分化成无害细胞;(8)阻止肿瘤细胞的扩散;(9)抑制基因突变或者染色体变形。虽然,与其他癌症治疗方案相比,中药具备多种优势,比如:极少产生耐药性和具备较高安全系数,但是,繁复多样的复方,较低的试验重复率和不严谨的实验步骤使得中医药抗癌性的研究无法深入。
Since cancer is a disease seriously threatening people’s lives, finding drugs against cancer has been one of popular topics among scientists over the world. In China, some researchers mainly focus on using traditional Chinese medicine, which is a kind of therapies unique to China, to treat cancer patients. Based on different studies, the underlying mechanism of Chinese herbs against cancer is classifed into 9 categories： （1） reverse multi-drug resistance （MDR） that cancer cells acquire; （2） be cytotoxic to cancer cell; （3） increase the activity of immune system, and stimulate the release of various cytokine; （4） inhibit angiogenesis; （5） suppress oncogene, stimulate apoptosis; （6） disrupt signal transduction; （7） stimulate cell division; （8） inhibit metastasis; （9） prevent gene mutation and DNA distortion. Although, comparing to other therapies, traditional Chinese medicine has advantages such as less MDR and less side effects, further studies regarding anti-cancer agents among Chinese traditional medicine are diffcult to continue, because of the complication of traditional Chinese medicine, less replication of research, and inconsistency of results.
出处
《中国卫生标准管理》
2017年第22期94-96,共3页
China Health Standard Management
关键词
中医药
抗癌机制
癌症治疗方案
Chinese medicine
anticancer mechanism
cancer therapies
