摘要
目的:比较HPV E6/E7 mRNA与HPV-DNA两种检测技术在宫颈病变筛查中的临床效度。方法:回顾性分析笔者所在医院妇产科门诊在笔者所在科行HPV检测并行组织活检病理学检查的患者826例,其中HPV E6/E7 mRNA组420例,HPV-DNA组406例,比较两组方法在筛查CIN1及以上病变的阳性率、灵敏度、特异度。结果:两种方法在筛查CIN1及以上病变的阳性率的效果相当,两组间阳性率比较差异无统计学意义(P>0.05),而HPV E6/E7 mRNA检测组的灵敏度(96.1%)高于HPV-DNA组(90.9%),特异度(89.4%)明显高于HPV-DNA组(71.4%),两组间灵敏度及特异度比较,差异有统计学意义(P<0.05)。结论:HPV E6/E7 mRNA作为一种新型的检测技术,其假阳性率低,结果更靠性切实,更能精准地筛查宫颈癌前病变,值得临床推广应用。
Objective： To compare the clinical validity of HPV E6/E7 mRNA and HPV-DNA in screening of cervical lesions.Method ： Regression analysis outpatient obstetrics and gynecology hospital in our department of HPV testing in parallel biopsy pathology examination of 826 cases, including HPV E6/E7 mRNA group 420 cases, HPV DNA-group 406 examples.The positive rate, sensitivity and specificity of the two groups were compared in the screening of CIN 1 and above lesions.Result： The effect of two methods on the screening of the positive rate of CIN1 and above lesions was comparable, the positive rate eomparisonbetweentbe two groups had no statistical significance（P〉0.05）, and HPV E6/E7 mRNA detection sensitivity（96.1%） than HPV-DNA group（90.9%）, specific degrees（89.4%） were significantly higher than those of HPV-DNA group（71.4%）, sensitivity and specific comparison between the two groups, the significant difference（P〈0.05）. Conclusion： HPV E6/E7 mRNA as a new kind of detection technology, has low false positive rate, and results in more sexual and accurate screening of precancerous lesions, which is worthy of clinical application.
出处
《中外医学研究》
2017年第29期75-77,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
