摘要
苯甲酸类化合物和薄荷醇在氯化亚砜(SOCl_2)与N,N-二甲基乙酰胺(DMAc)的共同作用下于二氯甲烷(DCM)中反应,高产率合成得到相应的苯甲酸薄荷酯。产物结构经~1H NMR,^(13)C NMR,和MS进行分析表征。该合成方法条件温和,操作简单,原料易得,产率较高,为苯甲酸薄荷酯及其衍生物的合成提供了一种新的实用方法。
Menthyl benzoate and its derivatives were synthesized from the corresponding benzoic acid,which react with menthol by using the combination of thionyl chloride（ SOCl2） and N,N-dimethylacetamide（ DMAc）in dichloromethane（ CH2Cl2） under the room temperature. The method proposed here has multiple advantages,such as mild condition,easy procedure,cheap ingredients and high yield,which provide a new and practical protocol for the synthesis of menthyl benzoate and its derivatives. The structures of products were characterized by ^1 H NMR,^13C NMR,and MS.
作者
周安西
郑大贵
祝显虹
罗年华
王媚媚
ZHOU Anxi ZHENG Dagui ZHU Xianhong LUO Nianhua WANG Meimei(Key Laboratory of Applied Organic Chemistry, Higher Institutions of Jiangxi Province, Shangrao Normal University, Shangrao 334001, China)
出处
《西北大学学报（自然科学版）》
CAS
CSCD
北大核心
2017年第5期705-710,共6页
Journal of Northwest University（Natural Science Edition）
基金
江西省教育厅科技基金资助项目(GJJ161059
GJJ151062)
信江英才866工程领军人才培养计划基金资助项目(2013-37)
上饶师范学院科技基金资助项目
