摘要
目的通过比较Freesurfer和基于体素的形态学测量软件(VBM8)分别与手动测量海马体积的相关性和一致性,探讨能够代替手动分割海马体积及脑部结构的自动测量方法。资料与方法分别收集青年(20~40岁)受试者67例、老年(60~80岁)受试者75例,全脑MRI扫描后分别使用手动分割、导入Freesurfer和VBM8中获得海马体积,应用Pearson相关分析和组内相关系数(ICC)分别统计Freesurfer和VBM与手动测量的相关性,用Bland-Altman散点图分析一致性。结果 Freesurfer、VBM与手动测量的相关性较高,青年组Freesurfer和VBM左右两侧r值分别为0.633、0.679和0.666、0.703,老年组r值分别为0.627、0.765和0.663、0.708;而ICC有明显差异,Freesurfer测得青年组(ICC=0.377、0.502)>老年组(ICC=0.307、0.459);但总体上ICC_(VBM)>ICC_(Freesurfer),右侧海马体积>左侧。由Bland-Altman散点图显示VBM与手动测量的一致性高于Freesurfer。结论 Freesurfer可局限性地用于青年受试海马体积测量;而VBM较Freesurfer可更准确地代替手动分割以测量成人海马体积,可应用于海马相关临床疾病或实验所需要的体积测量。
Purpose To explore an automatic measurement method to replace the manual segmentation of hippocampal volume and brain structure by comparing the relevance and consistency between Freesurfer, as well as voxel based morphometry software（VBM8）, and manual measurement of hippocampal volume, respectively. Materials and Methods Totally 67 young subjects（aged 20-40 years） and 75 elderly subjects（aged 60-80 years） were collected separately. After the whole brain MRI scan, the volume of the hippocampus was obtained by manual segmentation, importing to Freesurfer and VBM8 software respectively. Pearson correlation analysis and intraclass correlation coefficient（ICC） were used to statistically analyze the correlation of Freesurfer and VBM with manual measurement. Meanwhile, Bland-Altman scatter plot was used to reflect the consistency. Results Freesurfer and VBM were both highly related with manual measurement. The left and right r values of Freesurfer and VBM were 0.633, 0.679 and 0.666, 0.703, respectively in the young group, and 0.627, 0.765 and 0.663, 0.708, respectively in the elderly group; while ICC results showed an obvious difference. The value measured by Freesurfer in young group（ICC=0.377, 0.502） was larger than that in the elderly group（ICC=0.307, 0.459）. However, on the whole, ICC VBM was larger than ICC Freesurfer and right hippocampal volume was larger than left one. The Bland-Altman diagram showed that the consistency of VBM with manual measurement was better than that of Freesurfer. Conclusion Freesurfer can be applied locally on the measurement of hippocampal volume in young subjects. VBM is more accurate than Freesurfer in replacing manual segmentation for measurement of adult hippocampal volume and for volume measurements used in hippocampus related clinical diseases or needed in experiments.
出处
《中国医学影像学杂志》
CSCD
北大核心
2017年第9期646-650,共5页
Chinese Journal of Medical Imaging
关键词
海马
磁共振成像
软件
图像处理
计算机辅助
成年人
老年人
Hippocampus
Magnetic resonance imaging
Software
Image processing, computer-assisted
Adult
Aged
