摘要
目的:研究超微粉碎对血竭-红花混合粉体稳定性的影响。方法:将混合细粉及微粉分别置于高温、高湿及光照环境中,定期考察2种粉体的含水量、接触角、有效成分含量及其溶出行为。结果:高温下,微粉含水量、细粉的羟基红花黄色素A(HSYA)和血竭素含量均显著降低,微粉2种有效成分含量保持稳定。高湿下,微粉HSYA和血竭素含量变化量均显著低于细粉。光照下,细粉和微粉接触角均显著降低,细粉HSYA含量先于微粉发生显著变化,微粉血竭素含量先于细粉发生显著变化。高湿、高温和光照试验前后细粉中HSYA和血竭素溶出曲线均不具有等价性;微粉中仅HSYA在高湿试验前后的溶出、血竭素在高温试验前后的溶出不具有等价性。结论:影响因素试验对2种粉体润湿性变化趋势的影响一致。高温、高湿条件下微粉HSYA和血竭素的含量稳定性及光照条件下微粉HSYA的含量稳定性优于细粉。微粉中2种有效成分的溶出行为对影响因素的敏感度降低,溶出稳定性优于细粉。
Objective: To investigate the effect of the superfine pulverization on stability of Draconis Sanguis( Daemonorops draco Bl.)-Carthami Flos( Carthamus tinctorius L.) mixed powders. Methods: The common powder and micropowder were placed in the high temperature,the high humidity and the lighting conditions separately. The moisture content,wettability,content and dissolution of active ingredients were measured regularly. Result: Under the high temperature condition,the moisture content in the micropowder and the contents of HSYA and dracorhodin in the common powder reduced significantly,the contents of two active ingredients in the micropowder remained stable. Under the high humidity condition,the degree of the two active ingredients reduction in the micropowder was less than in the common powder. Under the lighting condition,the contact angle in the two powders reduced significantly,the change of the HSYA content in the common powder was prior to this in the micropowder,the change of the dracorhodin content in the micropowder was prior to this in the common powder. The dissolution curves of HSYA and dracorhodin in the common powder were not equivalent before and after the treatment of the high temperature,the high humidity and the lighting. The dissolution curve of HSYA before and after the treatment of the high humidity and the dissolution curve of dracorhodin before and after the treatment of the high temperature inthe micropowder were not equivalent. Conclusion: The stress testing had the same effect on variation tendency of wettability in two powders. Compared with the common powder,the content stability of HSYA and dracorhodin in the micropowder was better under the high temperature and the high humidity conditions,the content stability of HSYA in the micropowder was more stable under the lighting condition. The dissolution behavior of two active ingredients in the micropowder reduced the sensitivity to the stress testing. The dissolution stability of two active ingredients in the micropowder wa
出处
《江西中医药大学学报》
2017年第5期65-69,共5页
Journal of Jiangxi University of Chinese Medicine
基金
赣鄱英才555工程项目(赣财教字[2013]296)
关键词
超微粉碎
高温
高湿
光照
稳定性
Superfine Pulverization
High Temperature
High Humidity
Lighting
Stability