摘要
食物蛋白性小肠结肠炎（FPIES）是主要发生在婴幼儿和儿童的非IgE介导的胃肠道食物过敏反应，是可能具有潜在医疗风险的急症，重症患儿可发生低血压，甚至休克。目前对FPIES的认识水平还比较低。该病临床表现不典型，迄今尚无专门针对FPIES的非侵入性的诊断性标志物或诊断程序，若对FPIES整体认识不足，常被误诊或延迟诊断。目前主要靠病史及口服食物激发试验确诊。病史不清楚时，确诊前的鉴别诊断非常必要。严格回避过敏食物为主要治疗方式，急性发作期可能需要静脉补液，并对并发症进行处理。
Food protein- induced enterocolitis （FPIES） is a non- IgE mediated food allergy that occurs pri- marily in infants and children. Although the hypotension or even shock occurs and might need to go to emergency de- partment in severe patient with FPIES, there is an overall lack of knowledge about FPIES. Misdiagnosed or delayed diagnosis might be due to the absence of non - invasive diagnostic biomarker or diagnostic program specifically for FPIES, an overall lack of understanding of FPIES, and a combination of nonspecific symptoms. A clinical history and oral food challenges are the main diagnostic tools. Take care to exclude other potential causes before diagnosis established in the case of the history unclear. Avoidance of trigger food is the main treatment. During a acute episode, intravenous fluids may be required, and the complications need to be treated as well.
作者
詹学
Zhan Xue(Department of Gastroenterology, Children＇s Hospital of Chongqing Medical University, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2017年第19期1444-1451,共8页
Chinese Journal of Applied Clinical Pediatrics
关键词
非IgE介导的食物过敏
食物蛋白性小肠结肠炎
临床分型
诊断
鉴别诊断
管理
Non - IgE - mediated food allergy
Food protein - induced enterocolitis
Clinical classification
Diagnosis
Differential diagnosis
Management
