摘要
目的观察重组人生长激素对生长激素缺乏症(GHD)和特发性矮身材(ISS)患儿的影响。方法于2013年3月至2016年6月,在湖北省恩施市中心医院儿科随机选取47例ISS患儿及47例GHD患儿予以重组人生长激素治疗。对比ISS组患儿及GHD组患儿治疗前后的生长速率、体重、身高、身高标准差计数、骨龄及胰岛素样生长因子-1。结果治疗后与治疗前相比,两组患儿的生长速率、身高标准差计数及胰岛素样生长因子-1水平均明显增高,差异具有统计学意义(ISS组:t值分别为19.45、5.28、23.66,均P<0.05;GHD组:t值分别为20.29、5.71、22.77,均P<0.05);而体重、身高及骨龄均较治疗前增加,但差异无明显统计学意义(ISS组:t值分别为1.86、1.48、1.87,均P>0.05;GHD组:t值分别为1.78、1.43、1.81,均P>0.05)。治疗过程中两组患儿均无严重的不良反应出现。结论重组人生长激素对于ISS和GHD患儿的疗效显著,安全性高。
Objective To observe the influence of recombinant human growth hormone on treatment of children with growth hormone deficiency（ GHD） or idiopathic short stature（ ISS）. Methods From March 2013 to June 2016,47 cases of ISS children and 47 cases of GHD children were randomly selected from Enshi Central Hospital for recombinant human growth hormone therapy. The growth rate,body weight,height,height standard deviation score（ Ht SDS）,bone age and insulin-like growth factors-1（ IGF-1） were compared before and after treatment between ISS group and GHD group. Results Compared with those before treatment,the growth rate,Ht SDS and IGF-1 of two groups were significantly higher,and there were significant differences（ in ISS group t value was 19. 45,5. 28 and 23. 66,respectively,all P〈0. 05; in GHD group t value was 20. 29,5. 71 and 22. 77,respectively,all P〈0. 05）. The body weight,height and bone age of two groups were higher after treatment than before treatment,but the differences were not statistically significant（ in ISS group t value was 1. 86,1. 48 and 1. 87,respectively,all P〈0. 05; in GHD group t value was 1. 78,1. 43 and 1. 81,respectively,all P〈0. 05）. During the course of treatment,there was no serious adverse reaction in both groups. Conclusion Recombinant human growth hormone has significant efficacy and safety for children with ISS or GHD.
出处
《中国妇幼健康研究》
2017年第10期1281-1283,共3页
Chinese Journal of Woman and Child Health Research
关键词
重组人生长激素
生长激素缺乏症
特发性矮身材
生长发育
儿童
recombinant human growth hormone
growth hormone deficiency （GHD）
idiopathic short stature （ISS）
growth and development
children
