摘要
目的对氯吡格雷联合阿司匹林治疗不稳定型心绞痛的临床效果进行探究。方法随机选取我院2016年2月-2017年2月所收治的18例不稳定型心绞痛患者作为对照组,该组患者采用常规药物治疗,并在治疗过程中对患者的心绞痛发作次数、持续时间等进行记录;同期选取18例不稳定型心绞痛患者作为治疗组,予以该组患者氯吡格雷与阿司匹林相联合的方式治疗,并将该组所记录的心绞痛发作情况同对照组进行比较分析,以明确哪种治疗方式更为有效和安全。结果经一段周期的药物治疗后,治疗组的心绞痛平均持续时间及发作次数分别为(6.63±1.25)s、(1.52±0.42)次,明显少于对照组的(16.34±7.13)s、(5.63±1.21)次,且治疗组中共有17例患者符合治疗有效的标准,总治疗有效率达94.44%,而对照组中共有14例患者符合治疗有效的标准,总治疗有效率为77.78%,组间对比差异存在明显统计学意义(P<0.05)。结论针对不稳定型心绞痛,临床上采用氯吡格雷与阿司匹林相联合的方式进行治疗的效果是十分显著的,可减轻患者在临床上承受心绞痛的痛苦度,有利于缩短患者康复进程、提高患者生活质量等,可将这两种药物联合的治疗方式作为首选治疗方案。
Objective To investigate the clinical effect of clopidogrel combined with aspirin in the treatment of unstable angina. Methods A total of 18 patients with unstable angina who were admitted to our hospital from February2016 to February 2017 were enrolled as control group and were given routine pharmacotherapy, and the number of anginal attacks and duration were recorded. Another 18 patients with unstable angina who were treated during the same period of time were enrolled as treatment group and were given clopidogrel combined with aspirin. The condition of anginal attack was compared between the two groups to clarify which regimen was more effective and safer. Results After pharmacotherapy for a certain period of time, the treatment group had a significantly shorter duration of angina pectoris and a significantly lower number of anginal attacks than the control group（duration of angina pectoris：（6.63 ±1.25）s vs（16.34±7.13）s, P〈0.05; number of anginal attacks：（1.52±0.42）times vs（5.63±1.21）times, P〈0.05）. There was a significant difference in overall response rate between the treatment group and the control group [94.44%（17/18） vs 77.78%（14/18）,P〈0.05]. Conclusion Clopidogrel combined with aspirin has a marked clinical effect in the treatment of unstable angina and can alleviate the pain caused by angina pectoris, shorten the time to recovery, and improve patients＇ quality of life.Therefore, the combination of these two drugs can be used as the preferred treatment regimen.
出处
《心血管病防治知识（学术版）》
2017年第10期30-32,共3页
Prevention and Treatment of Cardiovascular Disease
