摘要
鲁米诺-铁氰化钾在Na OH介质中产生化学发光,加入微量甲巯咪唑对该体系化学发光有明显的抑制作用,建立了流动注射分析测定甲巯咪唑的新方法。优选体系中鲁米诺、铁氰化钾、碱性介质氢氧化钠浓度及实验仪器的最佳条件。在最佳条件下,甲巯咪唑浓度在5.0×10-7~2.0×10-5g·m L-1范围内与△I具有良好的线性关系,方法检出限为3.9×10-7g·m L-1。对2.0×10-6g·m L-1的甲巯咪唑溶液进行平行测定11次,测得相对标准偏差(RSD)为2.1%。该法应用于药物片剂中甲巯咪唑含量的测定,回收率在97.0%~105.0%。
In alkaline medium,methimazole has obvious inhibitory effect on Luminal-potassium ferricyanide chemiluminescence system. In this paper, a new flow injection chemiluminescence method for determination of methimazole was established. Luminol concentration, potassium ferricyanide concentration, sodium hydroxide concentration and other experimental parameters were optimized. Under the best condition, there was a good linear relationship between system relative luminescence intensity △I and methimazole concentration in the range of 5.0×10^-7~2.0×10^-5 g·m L^-1, the detection limit was 3.90×10^-7 g·m L^-1. Methimazole solution of 2.0×10^-6 g·m L^-1 was measured in 11 parallel determinations, the relative standard deviation（RSD） was 2.1%. The determination method was applied to detect actual methimazole content, the recovery was 97.0%~105.0%.
出处
《辽宁化工》
CAS
2017年第9期846-848,共3页
Liaoning Chemical Industry
基金
国家自然科学基金(51601167)
陕西省科技厅项目(2016KTZDGY-04-03)
关键词
化学发光
流动注射
甲巯咪唑
chemiluminescence
flow injection
methimazol
