摘要
目的探讨中度创伤性脑损伤（mTBI）患者血清神经元特异性烯醇化酶（NSE）、S100-β蛋白变化及其与认知功能障碍的相关性。方法采用回顾性病例系列研究分析2015年1月～2016年10月收治的87例mTBI患者临床资料，其中男50例，女37例；年龄14—60岁[（37．8±12．6）岁]。格拉斯哥昏迷评分（GCS）为9～12分，其中9～10分36例，11～12分51例。应用蒙特利尔认知评估量表（MoCA）评定患者的认知功能，MoCA〈26分为存在认知功能障碍（研究组，54例），MoCAt〉26分为无认知功能障碍（对照组，33例）。比较两组伤后中期血清NSE及S100-β蛋白水平及其与MoCA和GCS的相关性。结果与对照组NSE[（22．6±9．4）ng／L]、S100-β[（1．2±0．5）ng／L]比较，研究组NSE[（35．7±11．0）ng／L]、S100-β[（1．8±0．5）ng／L]水平较高（P〈0．01）。mTBI患者血清NSE、S100-β蛋白水平与MoCA呈负相关（r=-0．693，-0．721，P〈0．05）。与GCS 9～10分的患者血清NSE[（33．7±10．0）ng／L]、S100-β[（1．7±0．4）ng／L]比较，GCS11～12分的患者NSE[（19．4±9．0）ng／L]、S100-β[（1．3±0．5）ng／L]水平较低（P〈0．01）。mTBI患者血清NSE、S100-β蛋白水平与GCS呈负相关（r=-0．527，-0．796，P〈0．05）。结论mTBI后NSE、S100-β蛋白水平增高，与mTBI后认知功能障碍密切相关。
Objective To analyze the correlation of the levels of serum neuron specific enolase （NSE） and S100-β protein with cognitive impairment in patients with moderate traumatic brain injury （mTBI）. Methods A retrospective case series study enrolled 87 patients with mTBI treated from January 2015 to October 2016. There were 50 males and 37 females, aged 14-60 years [ （ 37.8 ± 12.6 ） years ]. The Glasgow Coma Score （GCS） was 9-12 points, among which were 9-10 points in 36 cases and 11- 12 points in 51. The cognitive function was assessed by the Montreal Cognitive Assessment Scale （MoCA）. The patients with MoCA 〈 26 points were assigned into cognitive impairment group （study group, 54 cases） , while the patients with MoCA 1〉 26 points was assigned into non-cognitive-impairment group （control group, 33 cases）. The levels of serum NSE and S100-β protein were compared, and the correlation of levels of serum NSE and S100-β protein with cognitive dysfunction （ assessed by MoCA and GCS） was analyzed. Results The levels of serum NSE and S100-β protein were （35.7 ±11.0）ng/L and （ 1.8 ±0.5 ） ng/L, respectively in study group, which were significant higher than that in control group [（22.6±9.4） ng/L and （1.2±0.5） ng/L, respectively] （P 〈0.01）. The levels of NSE [ （33.7 ± 10. 0） ng/L] and S100-β [ （ 1. 7 ± 0.4） ng/L ] in patients with GCS 9-10 points were higher than those of NSE [ （ 19.4± 9.0） ng/L] and S100-β [ （ 1.3 ± 0.5） ng/L] in patients with GCS 11- 12 points （P 〈 0. 01 ）. The levels of serum NSE and S100-β protein in mTBI patients were negatively correlated with the MoCA score （r = - 0. 693, - 0. 721, P 〈 0. 05 ） and GCS （ r = - 0. 527, - 0.796, P 〈 0.05 ）. Conclusion The levels of serum NSE and S100-β protein are increased, and are correlated to the occurrence of cognitive impairment in patient with mTBI.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2017年第10期886-889,共4页
Chinese Journal of Trauma
