摘要
目的制备盐酸普拉克索缓释微丸片。方法采用流化床包衣法制备盐酸普勒克索微丸,再将微丸与一定的辅料混合后压制成片。利用正交试验确定了微丸的最终处方。结果最优处方为10%碳酸氢钙用量、3%包衣增重率、25%柠檬酸三乙酯用量。自制缓释微丸片在分割后其释放行为与整片相似。结论自制缓释微丸片与市售缓释片的释放行为相似。
OBJECTIVE To prepare Pramipexole dihydrochloride sustained-release pellet tablets. METHODS The Pramipexole dihydrochloride sustained-release pellets were prepared by fluid bed coating technology. Pellets and suitable excipients were mixed,and then compressed to tablets. The orthogonal experiment was used to determine the final prescription. RESULTS The best prescription was selected as： 10% DCP,10% coating weight,3% silica dioxide weight,25% triethyl citrate. The release behavior of the split tablet was consistent with intact tablet. CONCLUSION The release behavior of the developed sustained-release pellet tablets and the marketed sustained-release tablets are consistent.
出处
《华西药学杂志》
CAS
CSCD
2017年第5期463-466,共4页
West China Journal of Pharmaceutical Sciences
关键词
盐酸普拉克索
缓释微丸
流化床包衣
微丸压片
正交试验
释放度
多单元缓释片
Pramipexole dihydrochloride
Sustained - release pellet tablets
Fluidized bed bottom - spray
Tabletting of pellet
Orthogonal experiments
Releasel
Multi - unit sustained - release tablets
