摘要
目的探讨一氧化氮呼出值(FeNO)预测放射性肺炎的价值。方法收集2016年8月至2017年2月收治的131例胸部肿瘤患者,对放疗前、后的FeNO水平进行检测,并分析大气道(50 ml/s流速)、小气道(200 ml/s流速)和肺泡放疗前、后FeNO水平与放射性肺炎分级的关系。结果 131例患者放疗前平均大气道FeNO为19.86 ppb,小气道为9.49 ppb,肺泡为2.84 ppb;仅肺泡FeNO放疗后上升明显,差异有统计学意义(P=0.015)。全组患者放疗后出现1级放射性肺炎43例,2级70例,3级18例,无4级及以上者。放疗前、后大气道、小气道、肺泡FeNO水平与放射性肺炎分级无关。结论肺泡FeNO在放疗后上升明显,但大、小气道放疗前、后FeNO水平不能预测放射性肺炎。
Objective To investigate the value of fractional exhaled nitric oxide （FeNO） in predicting radiation pneumonia. Methods One hundred and thirty-one thoracic tumor patients from Aug 2016 to Feb 2017 were received FeNO test before and after ra- diotherapy, and the relationship between FeNO of large airway （50 ml/s） , small airway （200 mL/s） , pulmonary alveolus and radiation pneumonia were analyzed. Results Of the 131 patients, the average FeNOs of large airway, small airway and pulmonary alveolus were 19. 86 ppb, 9.49 ppb and 2. 84 ppb before radiation. FeNO level of pulmonary alveolus increased significantly after radiotherapy（ P= O. 015）. After radiotherapy, grade 1, 2 and 3 radiation pneumonia were found in 43 patients, 70 patients and 18 patients. The FeNO level of large airway, small airway and pulmonary alveolus and had no relation with classification of radiation pneumonia. Conclusion FeNO of pulmonary alveolus rose significantly after radiotherapy. However, the FeNO level before and after radiotherapy cannot predict radiation pneumonia.
出处
《临床肿瘤学杂志》
CAS
2017年第9期827-830,共4页
Chinese Clinical Oncology
