摘要
目的探讨芒柄花素-单壁碳纳米管复合物(SWCNTs-FMN)的制备方法及其吸附动力学特征。方法采用溶液共混法制备芒柄花素-单壁碳纳米管复合物,并用激光粒度仪、红外光谱、差示扫描量热仪、X线衍射、扫描电镜等方法进行表征。结果所制得的SWCNTs-FMN复合物的包封率为(65.66±2.29)%,载药率为(25.25±3.48)%。羧基化单壁碳纳米管(SWCNTs-COOH)对芒柄花素(FMN)的吸附符合准二级吸附动力学(R2>0.999)。在150 min左右吸附基本达到平衡。SWCNTs-COOH对FMN的吸附满足Langmuir、Freundlish以及Dubinin-Radushkevich等温方程(R2>0.99)。结论溶液共混法制备的SWCNTs-FMN复合物制备工艺简单,重复性好;SWCNTs-COOH对FMN的吸附机制是从离子交换转化为化学吸附。
Objective To investigate the method for preparing SWCNTs-Fomononetin conjugates （ SWCNTs-FMN ） and the adsorption behavior of fomononetin on carboxylated single-walled carbon nanotubes （ SWCNTs-COOH ） . Methods The SWCNTs-FMN were prepared by solution mixing, and then the compositions were characterized by laser particle size analyzer, Fourier-transform infrared （ FTIR ） spectrometry, differential scanning calorimetry （ DSC） , x-ray diffractometry （ XRD） and scanning electron microscopy （ SEM） . Results It was evaluated that the entrapment efficiency was （ 65.66±2.29）%, and the loading capacity was （ 25.25±3.48）%. The adsorption of FMN on SWNTs-COOH achieved equilibrium after 150 min and could be explained by pseudo-second-order model （ R2〉0.999） . Langmuir, Freundlish and Dubinin-Radushkevich isotherm equations could well describe the thermodynamics process of FMN adsorbed onto SWCNTs-COOH （ R2〉0.99） . Conclusion The preparation of SWCNTs-FMN was practicable by solution mixing. The process was simple, and the SWCNTs-FMN had good repeatability. SWCNTs-COOH easily adsorbed FMN, and the adsorption mechanism was transformed from ionic exchange to chemical adsorption.
出处
《广东药科大学学报》
CAS
2017年第4期427-432,共6页
Journal of Guangdong Pharmaceutical University
基金
国家自然科学基金项目(81403111)
广东省大学生创新创业训练计划项目(201610573027)
