摘要
近年来,葡萄糖敏感高分子药物传递系统因其能够依据葡萄糖浓度变化自动连续地控制药物释放而备受关注.其中,基于苯硼酸(PBA)的葡萄糖敏感高分子载体以其较好的稳定性、长期储存性和可逆的葡萄糖敏感性能而被广泛研究,特别是基于PBA的葡萄糖敏感纳米药物传输体系成为该领域的研究热点.本文系统地概述了用于自调式药物传输的葡萄糖敏感PBA基高分子纳米药物载体,包括纳米胶束、纳米囊泡、纳米凝胶以及杂化纳米粒子等的研究进展,并对其发展方向和应用前景进行了展望.
Recently, glucose-sensitive polymer drug delivery systems have attracted growing attention, which control drug release automatically and continuously depending on the change of glucose concentration. Glucose-sensitive drug nanocarriers based on phenylboronic acid （PBA） have shown promising potential applications in the therapy of diabetes due to the great stability, long term storability, and reversible glucose-sensitivity. Particularly, the PBA-based glucose-sensitive polymer nanocarriers have become the research focus in this field. This review covers the recent development in the PBA-based glucose-sensitive nanocarriers, such as namomicelles, nanovesicles, nanogels, and hybrid nanoparticles. The development trend and application prospect of PBA-functionalized polymer nanocarriers in self-regulated drug delivery are also predicted.
作者
赵丽
黄琼卫
王立艳
盖广清
肖姗姗
毕菲
丁建勋
Li Zhao Qiongwei Huang Liyan Wang Guangqing Gai Shanshan Xiaot Fei Bi Jianxun Ding(College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, China Department of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun 130033, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ？ These authors contributed equally to this work)
出处
《中国科学：化学》
CAS
CSCD
北大核心
2017年第9期1057-1074,共18页
SCIENTIA SINICA Chimica
基金
国家自然科学基金(编号:51403075,51673190)
吉林省科技发展计划(编号:20170520153JH,20160204015SF)资助项目
关键词
葡萄糖敏感
苯硼酸
高分子
纳米载体
药物传递
糖尿病治疗
glucose-sensitivity
phenylboronic acid
polymer
nanocarrier
drug delivery
diabetes therapy
