摘要
目的建立测定归脾丸中铜(Cu)、铅(Pb)、汞(Hg)、砷(As)﹑镉(Cd)5种重金属含量的电感耦合等离子体质谱(ICP-MS)法。方法样品经过微波消解程序进行高压湿法消化后,分别以锗﹑铟﹑铋为内标,采用ICP-MS同时测定样品中Cu、Pb、Hg、As、Cd的含量。结果对于所测元素,校准曲线的相关系数均为0.999 9,线性关系良好,方法的平均回收率为90.3%~103.6%,RSD为1.6%~3.9%。结论本方法快速、简便、灵敏度高,适用于归脾丸中5种重金属残留量的测定。
OBJECTIVE To establish a method for the determination of copper（ Cu）,lead（ Pb）,mercury（ Hg）,arsenic（ As）,cadmium（ Cd） in Guipi pills by inductively coupled plasma mass spectrometry（ ICP-MS）. METHODS The samples were digested by closed-vessel microwave,the contents of above-mentioned five kinds of elements were determined by ICP-MS,with Ge,In and Bi as the internal standards. RESULTS For all of the analyzed heavy metals,the correlative coefficient of the calibration curves was 0.999 9.The average recoveries were in the range of 90. 3%-103. 6%,the RSDs were in the range of 1. 6%-3. 9%. CONCLUSION The established method is simple,rapid and highly sensitive,and can be used to determine the five kinds of heavy metal elements in Guipi pills.
作者
朱玉芳
谢健鸣
隆颖
ZHU Yufang XIE Jianming LONG Ying(Guangdong Institute for Drug Control, Guangzhou , Guangdong 510180, China)
出处
《今日药学》
CAS
2017年第9期602-605,共4页
Pharmacy Today
基金
广东省中医药局科研课题(20151048)
