摘要
目的探讨安维汀辅助常规化疗治疗非小细胞肺癌的临床效果。方法选择48例非小细胞肺癌患者为研究对象，随机分为两组，对照组24例，给予常规化疗治疗，观察组24例，在常规化疗基础上加用安维汀治疗，观察治疗后两组疗效及安全性。结果总疗效：对照组完全缓解（CR）率为12．50％，总有效率为58．33％；观察组CR率为25．00％，总有效率为79．17％，两组比较差异有统计学意义（P〈0．05）。生活质量：对照组提高率为12．50％，总有效率为37．50％；观察组提高率为37．50％，总有效率66．67％，两组比较差异有统计学意义（P〈0．05）。对照组白细胞减少、骨髓抑制、恶心呕吐、血小板减少、肝素功能损害发生率分别为45．83％、29．17％、66．67％、37．50％、41．67％，观察组相对应并发症发生率分别为29．17％、16．67％、45．83％、20．83％、20．83％，两组比较差异有统计学意义（P〈0．05）；两组治疗前后CD3＋、CD4＋、CD8＋、CD4＋／CD8＋比较差异均有统计学意义（P均〈0．05），治疗后两组比较差异也有统计学意义（P均〈0．05）。结论安维汀辅助常规化疗治疗非小细胞肺癌临床效果显著，能提高患者生活质量，降低并发症发生率。
Objective To investigate the efficacy and safety of avastin adjuvant regular chemotherapy for non-small cell lung cancer. Methods Forty-eight cases of non-small cell lung cancer were divided into two groups, the 24 cases in control group were treated with regular chemotherapy, and the 24 cases in observation group were treated with regular chemotherapy combined with avastin. The efficacy and safety were observed between the two groups. Results Total curative effect： those the total effective rate and CR rate in the control group were 58.33% and 12.50% , and in the observation group were 79. 17%, 25.00% , the differences were significant （ P 〈 0. 05 ）. Quality of life ： the increase rate and total efficiency in the control group were 12.50% and 37.50%, and those in the observation group were 37.50% and 66. 67% , the differences were also significant （ P 〈 0. 05 ）. The incidence of leukopenia, bone marrow suppression, nausea or vomiting, thrombocytopenia, heparin dysfunction incidence in the control group were respectively 45.83%, 29. 17% , 66. 67%, 37.50%, 41.67% ; the corresponding complication rates in the observation group were 29. 17%, 16.67%, 45.83%, 20. 83%, 20. 83%, the differences were significant （P 〈 0.05 ）. Before and after treatment, the CD3 ＋ , CD4 ＋ , CD8＋ , CD4 ＋/ CD8 ＋ in the two groups were significantly different （P 〈 0. 05 ） ; After treatment, there was significant difference between the two groups （P 〈 0. 05 ）. Conclusions Avastin adjuvant regular chemotherapy for non-small cell lung cancer is effective, it can improve the quality of life and reduce the incidence of complications.
作者
张克
路遥
王晓东
Zhang Ke Lu Yao Wang Xiaodong(Department of Thoracic Surgery Jinghua Hospital, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China)
出处
《中国实用医刊》
2017年第18期19-21,共3页
Chinese Journal of Practical Medicine
关键词
安维汀
化疗
非小细胞肺癌
临床效果
Avastin
Chemotherapy
Non-small cell lung cancer
Clinical results
