摘要
目的:比较三种不同肠内营养(EN)输注方式对慢性阻塞性肺疾病急性发作期(AECOPD)无创通气病人氧疗效果产生的影响。方法:采用前瞻性对照研究方法,将96例AECOPD行无创通气治疗病人按入院顺序依次分为连续喂养组、间歇连续喂养组和定时灌注组,每组各32例。比较三组病人EN治疗后第3、5、7天动脉血p H值、PaO_2(氧分压)、PaCO_2(二氧化碳分压)、PaO_2/FiO_2(氧合指数)等指标,同时对比三组病人日均费用、入住ICU天数、机械通气天数等综合指标。结果:连续喂养组和间歇连续喂养组治疗后第7天的p H值、入住ICU时间、机械通气时间均优于定时灌注组(P<0.05)。连续喂养组病人的营养支持费用明显低于间歇连续喂养组(P<0.05)。结论:两种连续喂养方式均能有效改善无创通气的AECOPD病人缺氧状况,降低病人入住ICU天数,缩短机械通气时间,降低费用。
Objective： Comparison of oxygen therapy effect between three different enteral nutrition solutions was carried out on AECOPD patients with non-invasive ventilation. Methods： A total of 96 patients with acute exacerbation of COPD were divided into three groups of 32 respectively according to the admission order in this prospective study： a continuous feeding group, an intermittent feeding group, and a regular bolus feeding group. Arterial blood gas parameters including PH, PaO2, PaCO2, PaO2/FiO2 of three groups on third day, fifth day,seventh day were recorded and compared to evaluate the enteral nutrition effect, and meanwhile nutritional support costs, duration of mechanical ventilation, and length of ICU stay between groups were also studied. Results： PH Values of continuous feeding group and intermittent feeding group on 7th day are7.38±0.04、7.39±0.01 respectively, better than that of regular bolus feeding group（P〈0.05）. ICU stay period and duration of mechanical ventilation for continuous feeding group are 12.83±3.00 days and 9.50±1.45 respectively, for the intermittent feeding group are 11.90±2.35 and 9.59±1.50 respectively, the two groups gain significant cost-effective advantages compared to the regular bolus feeding group.（P〈0.05）, for nutrition support costs, continuous feeding is less than the intermittent feeding.（P〈0.05）. Conclusion： Continuous feeding and intermittent feeding could significantly improve hypoxia symptom and reduce the length of ICU stay and shorten duration of mechanical ventilation in COPD patients compared with regular bolus feeding group.
作者
钟孟秋
张克标
古满平
ZHONG Meng-qiu ZHANG Ke-biao GU Man-ping(Emergency Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China)
出处
《肠外与肠内营养》
北大核心
2017年第4期233-236,共4页
Parenteral & Enteral Nutrition
基金
重庆医科大学附属第一医院院级课题项目(HLJJ2015-20
HLJJ2012-16)
关键词
慢性阻塞性肺疾病
无创通气
肠内营养
通气效果
鼻饲
Chronic obstructive pulmonary disease
Noninvasive ventilation
Enteral nutrition
Oxygen therapy
Nasal feeding
