摘要
钙结合蛋白S100P属于S100家族成员之一,具有介导细胞间连接、蛋白质磷酸化、转导Ca^(2+)信号及转录等功能,通过细胞内外功能的调节,参与细胞的异常增生和恶变,并与肿瘤的发生、发展、临床分期、转移、预后相关。S100P在食管癌、胃癌、肝癌、胆管癌等消化系统肿瘤中异常表达,其有可能作为一种潜在的肿瘤标志物用于消化系统肿瘤的早期诊断。深入研究S100P在消化系统肿瘤中的作用可能为消化系统肿瘤的早期诊断、肿瘤分期、治疗和预后提供新的途径。
Calcium binding protein S100 P,which belongs to the S100 family,has the functions of mediating intercellular connection,protein phosphorylation,transduction of Ca^（2＋）signal and transcription and is involved in abnormal proliferation and malignant transformation of cell through the regulation of intracellular and extracellular function,thus is associated with the occurence,development,clinical staging,metastasis,and prognosis of tumor. S100 P is abnormally expressed in digestive system tumors such as esophageal carcinoma,gastric cancer,liver cancer,carcinoma of bile duct and so on,therefore it may be used as a potential tumor marker for early diagnosis of digestive system tumors. In-depth study the effect of S100 P in digestive system tumors may provide a new approach for the early diagnosis,tumor staging,treatment and prognosis of digestive system tumors.
出处
《医学综述》
2017年第19期3796-3800,共5页
Medical Recapitulate
关键词
消化道肿瘤
食管癌
胃癌
钙结合蛋白S100P
Gastrointestinal carcinomas
Esophageal carcinoma
Gastric cancer
Calcium binding protein S100P
