摘要
目的:系统评价脑卒中后癫痫发病的主要危险因素,为临床对该病的防治提供一定的依据和借鉴。方法:由两名检索人员通过计算机检索Pub Med、EMbase、中国知网CNKI、CBM、万方数据库、维普数据库VIP,检索时间均为建库时间至2016年4月25日。全面搜集脑卒中后癫痫发病危险因素的病例-对照研究。两名评价者依据本荟萃分析的纳入及排除标准独立对文献筛选、资料提取及质量评价后,采用Rev Man5.3软件进行Meta分析。结果:共有8篇文献纳入到本研究,共纳入3423例研究对象,其中脑卒中发生癫痫439例,脑卒中后未发生癫痫2984例。Meta分析结果显示:颅内压增高、多脑叶病灶、脑出血、脑梗死、电解质紊乱、病灶累及皮质与脑卒中癫痫的发病相关,其OR值(95%CI)分别为0.3(0.15,0.61)、6.36(4.75,8.51)、1.54(1.24,1.93)、0.61(0.49,0.76)、0.23(0.14,0.37)、5.04(4.02,6.32)。结论:脑卒中后癫痫的发病与颅内压增高、多脑叶病灶、脑出血、脑梗死、电解质紊乱、病灶累及皮质有关,可为临床脑卒中后癫痫的预防提供依据。
Objective： To explore the main risk factors for Epilepsy after stroke, so as to provide basis for clinical on prevention and control of the disease. Methods： Such databases as PubMed, EMbase, CNKI,CBM, Wanfang and VIP database were electronically searched by two retrieval personnel to collect case-control studies on risk factors for epilepsy after stroke. Retrieval time are built library until April 25th in 2016. Meanwhile, relevant studies were also manually retrieved. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality. Then, Meta-analysis was performed using RevMan 5.3. software. Results： 8 studies were collected, involving 3423 participants including 439 cases of epilepsy after stroke, 2984 cases without epilepsy after stroke. Meta-analysis results show that the increased intracranial pressure, cerebral lobe lesions, cerebral hemorrhage, cerebral infarction, electrolyte disorder, lesions involving cortex associated with the onset of epilepsy after stroke, with pooled OR （95%C/） values of 0.3 （0.15,0.61）,6.36 （4.75,8.51）,1.54 （1.24,1.93）,0.61 （0.49,0.76）,0.23 （0.14,0.37）,5.04 （4.02,6.32）, respectively. Conclusion： The increased intracranial pressure, cerebral lobe lesions, cerebral hemorrhage, cerebral infarction, electrolyte disorder, lesions involving cortex associated with the onset of epilepsy after stroke.
出处
《中医药导报》
2017年第18期112-115,122,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
