摘要
目的研究亚低温脑保护在创伤性颅脑损伤治疗中的临床应用效果。方法选择我院2013年1月~2016年1月收治入院的60例创伤性颅脑损伤患者作为研究对象,随机分为亚低温组和对照组,各30例。对照组仅给予开颅手术、抗炎、止血、脱水等基础治疗,亚低温组在对照组的基础上均于伤后24 h内行亚低温治疗,体温控制在33~35℃,持续~7 d,比较两组的总有效率,对治疗前后的脑水肿体积、血清SOD及MDA水平进行评价,记录两组治疗1年时的KPS评分及两组治疗过程中的副作用发生率。结果亚低温组的总有效率为46.7%,高于对照组的23.3%,差异有统计学意义(P<0.05)。两组治疗前的脑水肿体积、血清SOD及MDA水平比较,差异无统计学意义(P>0.05)。两组治疗后的脑水肿体积、血清SOD及MDA水平明显低于治疗前,差异有统计学意义(P<0.05)。亚低温组治疗后的脑水肿体积、血清SOD及MDA水平明显低于对照组,差异有统计学意义(P<0.05)。亚低温组治疗1年时的KPS评分明显优于对照组,差异有统计学意义(P<0.05)。两组治疗过程中副作用发生率比较差异无统计学意义(P>0.05)。结论亚低温脑保护在创伤性颅脑损伤治疗中的临床应用效果确切,可减轻脑水肿,改善患者预后,值得推广。
Objective To study the clinical application effect of mild hypothermia in brain protection of patients with traumatic brain injury.Methods 60 patients with traumatic brain injury admitted to our hospital from January 2013 to January 2016 were selected as the subjects,and all patients were randomly divided into the mild hypothermia group and the control group,30 cases in each group.The patients in the control group were given only craniotomy,anti-inflammato- ry,hemostasis,dehydration and other basic treatment.In the mild hypothermia group,the hypothermia treatment was per- formed 24 hours after the injury,and the body temperature was controlled at 33-35℃ for 5-7 days on the basis of the control group.The total effective rate of the two groups was compared.Before and after treatment,the brain edema vol- ume,serum SOD and MDA levels were evaluated.The KPS score and the side effects of the two groups were recorded. Results The total effective rate was 46.7% in the mild hypothermia group,which was higher than 23.3% in the control group,with significant difference （P〈0.05）.There was no significant difference in the levels of SOD and MDA,the brain edema volume between the two groups （P〉0.OS）.The brain edema volume,the levels of SOD and MDA in the brain tissue of the two groups after treatment was significantly lower than that before treatment,with significant difference （P〈0.05）. The brain edema volume,the levels of SOD and MDA in the brain tissue of the mild hypothermia group after treatment was significantly lower than that of the control group,with significant difference （P〈0.OS）.The KPS score in the mild hy- pothermia group was significantly better than that in the control group,with significant difference （P〈0.OS）.There was no significant difference in the incidence rate of side effects between the two groups （P〉0.05）.Conclusion The clinical ap- plication of mild hypothermia in the treatment of traumatic brain injury is effective,which can reduce brain edema and improve the pro
出处
《中国当代医药》
2017年第27期21-24,共4页
China Modern Medicine
基金
广东省梅州市科技计划项目(2016B042)
关键词
亚低温脑保护
创伤性颅脑损伤
脑保护
效果
Mild hypothermia brain protection
Traumatic brain injury
Brain protection
Effect
