摘要
目的探讨放射性125I粒子组织间植入联合静脉化疗对Ⅲb期、Ⅳ期非小细胞肺癌(NSCLC)的疗效。方法Ⅲb期、Ⅳ期NSCLC患者按治疗方法不同分为2组。联合组(n=43)125I粒子植入3天后,联合TP(紫杉醇+顺铂)方案或GP(吉西他滨+顺铂)方案化疗;对照组(n=47)仅接受TP或GP方案化疗。比较2组治疗有效率、生存率和中位生存期。结果联合组和对照组Ⅲb期患者的近期局部总有效率分别为84.00%、48.28%,Ⅳ期患者有效率为72.22%、33.33%,组间差异均有统计学意义(P均<0.05)。联合组和对照组Ⅲb期患者1、2年生存率分别为67.80%、36.00%和37.90%、13.83%,差异有统计学意义(P<0.05),两组中位生存期分别为15.7个月、8.6个月;联合组和对照组Ⅵ期患者1、2年生存率分别44.44%、16.70%和22.22%、11.10%,差异无统计学意义(P>0.05),两组中位生存期分别为8.9个月、6.0个月。结论 125I粒子组织间植入联合静脉化疗对Ⅲb期、Ⅳ期NSCLC患者的近期疗效良好,对于Ⅲb期NSCLC患者,联合治疗方案可提高患者的生存率。
Objective To investigate the efficacy of implantation of radioactive iodine-125 （125↑Ⅰ ） seeds combined with chemotherapy in treatment of stage Ⅲb and Ⅳ non-small cell lung cancer （NSCLC）. Methods Ninety patients with stage Ⅲb and Ⅳ NSCLC were divided into two groups. The combined group （n=43） reeeived chemotherapy with TP （paclitaxe plus cisplatin） or GP （gemcitabine plus cisplatin） 3 days after 125↑Ⅰ particles implantation, and the control group （n= 47） only received TP or GP chemotherapy. The effective rate, 1-year and 2-year survival rate, the median survival time were compared between the 2 groups. Results The total effective rates of the combined group and the control group of stage Ⅲb NSCLC were 84.00% and 48.28%, and the effective rates of stage Ⅳ NSCLC were 72.22% and 33.33% （both P〈0.05）. The 1-year and 2-year survival rate of the combined group and control group of stage Ⅲb NSCLC were 67.80%, 36.00% and 37.90%, 13.83%, respectively （both P〈0.05）. The median survival time was 15.7 months and 8. 6 months. However, the survival rates of the combined group and the control group of stage Ⅳ NSCLC were 44. 44%, 16.70% and 22. 22%, 11.10%, respectively, while the difference was not statistically significant （P〉0.05）. The median survival time was 8. 9 and 6.0 months. Conclusion The implantation of radioactive 125↑Ⅰ seeds combined with chemotherapy can obtain a significant efficacy in the treatment of stage Ⅲb and stage Ⅳ NSCLC. For patients with stage Ⅲb NSCLC, combined therapy can improve the survival rate.
出处
《中国介入影像与治疗学》
CSCD
北大核心
2017年第10期592-596,共5页
Chinese Journal of Interventional Imaging and Therapy
基金
国家卫计委医学科研专项项目(w2015xr13)
安徽省科技攻关项目(1704a0802152)
