摘要
目的:分析免疫性血小板减少症(ITP)患儿血清IgE水平的变化,探讨血清IgE水平与ITP发病机制的相关性。方法:选取2014年8月至2016年3月在我院住院的62例新诊断ITP患儿,检测血清IgE水平,其中血小板计数(PLT)<20×109/L患儿22例为ITP 1组,20×109/L<PLT<70×109/L患儿40例为ITP 2组;选取同期健康体检儿童30例为对照组。比较两组ITP患儿IgE水平、IgE阳性(IgE>100 IU/m L)患儿与幽门螺杆菌(Hp)及血小板相关IgG抗体(PAIgG)阳性率的关系。结果:ITP 1组和ITP 2组IgE水平阳性率高于对照组(χ~2=11.89,P<0.05);ITP 1组和ITP 2组IgE水平阳性率均高于对照组(χ~2分别为9.28、8.23,P<0.05)。IgE阳性与IgE阴性患儿中Hp检测阳性率比较差异无统计学意义(χ2=0.069,P>0.05);IgE阳性与IgE阴性患儿中PAIgG检测阳性率比较差异无统计学意义(χ~2=0.006,P>0.05)。结论:血清IgE水平的升高可能参与了ITP的发病机制。
Objective： To analyze the changes of children＇s serum immunoglobulin E （IgE） levels in children with immune thrombocytopenia （ITP）.Methods： The data of 62 ITP children who were hospitalized in our hospital between August,2014 to March,2016 were collected.Thirty children of health were selected as the control group.The serum IgE levels of all children were detected.The ITP children were divided into two groups based on platelet （PLT）,22 cases （PLT20×109/L） in ITP 1 group and 40 cases （20×109/LPLT70×109/L） in ITP 2 group.The relationship between IgE levels,IgE positive （IgE100 IU/m L） and Helicobacter pylori （Hp） and platelet related IgG antibody （PAIgG） positive rate were compared between the two groups.Results： The peripheral blood serum IgE positive rate of ITP children was higher than the control group （χ^2= 11.89,P〈0.05）.The IgE positive rate of ITP 1 group and ITP 2 group were higher than the control group （χ^2= 9.28,8.23,P〈0.05）.Hp positive rates of the children with IgE positive and IgE negative had no statistical significance （χ^2= 0.069,P〉0.05）.PAIgG positive rates of the children with IgE positive and IgE negative had no statistical significance （χ^2= 0.006,P〉0.05）.Conclusion： The increase of serum IgE levels may be involved in the pathogenesis of ITP.
作者
张晓燕
白涛敏
刘春风
周南
Zhang Xiaoyan Bai Taomin Liu Chunfeng Zhou Nan(Children＇ s Hospital of Shaanxi Provincial People＇ s Hospital, Shaanxi Xi＇an 710068, China)
出处
《儿科药学杂志》
CAS
2017年第10期4-6,共3页
Journal of Pediatric Pharmacy
基金
陕西省自然科学基础研究计划项目
编号2014JM2-8184
