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小剂量化疗与手术治疗儿童孤立性骨嗜酸性肉芽肿的效果比较 被引量:3

Comparative Study between Low-dose Chemotherapy and Surgery for Isolated Eosinophilic Granuloma Bone Lesions in Children
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摘要 【目的】探讨小剂量化疗、手术及手术加术后辅助小剂量化疗这三种不同的方法在儿童孤立性骨嗜酸性肉芽肿(SBL-EG)治疗上的有效性及可行性。【方法】回顾性分析了149例SBL-EG的儿童患者,其中86例接受小剂量化疗,33例行手术治疗,30例接受手术及术后辅助小剂量化疗。比较三组患者的住院时间、症状缓解时间、恢复时间、治疗费用、并发症及无复发生存时间(RFS)。【结果】小剂量化疗组的住院时间、症状缓解时间、恢复时间及治疗费用均低于手术或手术加化疗组(P<0.05),而手术组与手术加化疗组在上述4个方面的对比均无明显统计学差异(P>0.05)。小剂量化疗组及手术加化疗组中化疗药物相关的副作用包括恶心(8.62%),转氨酶升高(7.76%),轻度脱发(4.31%),抵抗力下降(21.55%),生长发育迟滞(10.34%)及满月脸(7.76%)。小剂量化疗组及手术加化疗组的RFS(147月及126月)明显长于手术组(114月)(P=0.005及0.019)。然而,小剂量化疗组及手术加化疗组的RFS差异无统计学意义(P=0.732)。【结论】在SBL-EG的儿童患者治疗上,相对于手术或手术加化疗而言,小剂量化疗是一种创伤小、恢复快、经济、安全有效的方法。 【Objective】To comprehensively compare the feasibility of three different treatment strategies consisting of low-dosechemotherapy(LDC),surgery and surgery with adjuvant low-dose chemotherapy(SLDC)for children with solitary bone lesions ofeosinophilic granuloma(SBL-EG).【Methods】We retrospectively reviewed the records of 149 pediatric patients with SBL-EG at ourinstitutions from 2002 to 2014. Our study included 86 patients who received LDC,33 patients who received surgery and 30 patientswho received SLDC. The duration of hospital stay,time to symptom relief,recovery time,cost,complications and relapse-free sur-vival(RFS)of each strategy were analyzed.【Results】Hospital stay,time to symptom relief,recovery time and cost in the LDCgroup were significantly shorter or less than those in the surgery or SLDC group(P〈0.05). No statistically significant differenceswere observed in the above-mentioned factors between the surgery and SLDC groups(P〉0.05). Chemotherapy-related adverseevents in the LDC and SLDC groups included nausea(8.62%),aminotransferase elevation(7.76%),slight hair loss(4.31%),immunity decline(21.55%),growth retardation(10.34%)and moon face(7.76%). LDC and SLDC treatment resulted in asignificantly longer RFS(147 months and 126 months,respectively)than surgery alone(114 months)(P = 0.005 and 0.019,respectively). However,there was no statistically significant difference in RFS between the LDC and SLDC groups(P = 0.732).【Conclusions】Compared with surgery or SLDC,LDC appears to promote more rapid recovery,less invasion,increase safety and eco-nomic treatment strategy for pediatric patients with SBL-EG.
作者 利洪艺 温丽丽 谢显彪 尹军强 汪校帅 张嘉俊 李洪波 黄纲 LI Hong-yi WEN Li-li XIE Xian-biao YIN Jun-qiang WANG Xiao-shuai ZHANG Jia-jun LI Hong-bo HUANG Gang(Department of Orthopaedic Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China State Key Laboratory of Oncology in Southern China//Sun Yat-sen University Cancer Center, Guangzhou 510060, China)
出处 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2017年第5期693-698,共6页 Journal of Sun Yat-Sen University:Medical Sciences
基金 国家自然科学基金面上项目(81572638) 广东省自然科学基金(S2013010015384 2014A030313219)
关键词 嗜酸性肉芽肿 单发 儿童 化疗 手术 eosinophilic granuloma isolated children chemotherapy surgery
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