摘要
目的分析脂溶性维生素药品不良反应(ADR)发生的临床特点及规律,为儿科临床安全用药提供参考。方法回顾性分析医院2013年1月-2016年12月收集上报的49例脂溶性维生素ADR报告。结果 49例患儿中2013年5例(10.21%),2014年25例(51.02%),2015年15例(30.61%),2016年4例(8.16%);发生ADR的季节以冬季为主28例(57.14%),其次为春季18例(36.73%);脂溶性维生素(Ⅰ)发生ADR 40例(81.63%);性别男24例(48.98%),女25例(51.02%);年龄1.7~12.0岁;感染性疾病38例(77.55%);患儿有个人或家族过敏性因素39例(79.59%)。49例ADR累及全身多个器官和(或)系统157例次,其中最常见的是皮肤及其附件损害68例次(43.31%)。49例患儿根据实际需要进行抗过敏、抗休克、维持生命体征等综合治疗,全部转归良好,无后遗症发生。结论脂溶性维生素是易致敏药物,ADR易在有过敏性因素的患儿中出现,感染本身可能是诱发ADR的一个因素,在临床工作中合理使用脂溶性维生素可减少ADR的发生。
Objective To analyze the characteristics fat-soluble vitamin lead to pediatric ADR in the hospital, and provide reference for clinical safe drug use. Methods Retrospective study was adopted to statistically analyze fat-soluble Vitamin lead to pediatric ADR re-ports in the hospital from January 2013 to December 2016. Results In the 49 ADR reports,5 cases（10.21% ） in 2013,25 cases（51.02% ） in 2014,15 cases（30.61% ） in 2015,4 cases（＆ 16% ） in 2016;28 cases （57.14%） of ADR occurred in winter,followed by 18 cases（36.73% ） in spring;There were 40 cases（81.63% ） of ADR in fat -soluble vitamins （ I ） ;24 cases （48.98 % ） were Male,25 cases （51.02% ） were female; 1.7 to 12.0 years old ; 38 cases （77.55%） were infectious diseases ;39 cases （79.59%） had personal or family allergic factors. 49 cases（ 157 cases） ADR involving the body multiple organs and/or system,68 cases（43.31% ） damage to the skin and its accessories. 49 cases of children given anti-allergy, anti-shock, maintenance of vital signs and other comprehensive treatment, all good results, no sequelae occurred. Conclusion Fat-soluble vitamins are easily sensitized drugs, children with allergic factors prone to ADR,the infec- tion itself may be a factor in the induction of ADR, in clinical work, the rational use of fat-soluble vitamins can reduce the incidence of ADR.
出处
《临床合理用药杂志》
2017年第25期11-12,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
脂溶性维生素
药品不良反应
合理用药
Fat-soluble Vitamin
Adverse drug reaction
Rational drug use
