摘要
结核病是严重危害公众健康的全球性公共卫生问题,耐药结核病尤其是耐多药结核病的传播使结核病疫情更加严峻。利福平是重要的一线抗结核药之一,并且作为耐多药结核病的替代标志物。因此了解结核分枝杆菌耐利福平机制对预防及控制耐药结核病有着重要意义。本文就结核分枝杆菌耐利福平机制及其研究进展进行综述。
Tuberculosis is a global public health problem that seriously endanger public health, and the spread of drug-resistant tuberculosis, especially multidrug-resistant tuberculosis （MDR-TB）, makes tuberculosis more severe. Rifampicin is one of the important first-line anti-tuberculosis drugs and serves as an alternative marker for MDR-TB. Therefore, understanding the mechanism of rifampicin resistance in Mycobacterium tuberculosis is of great significance to the prevention and control of drug-resistant tuberculosis. In this paper, the mechanism of rifampicin resistance in Myco-bacterium tuberculosis and its research progress is reviewed.
出处
《海南医学》
CAS
2017年第17期2853-2856,共4页
Hainan Medical Journal
基金
国家自然科学基金(编号:81360002)
关键词
结核分枝杆菌
利福平
耐药
机制
Mycobacterium tuberculosis
Rifampicin
Drug resistance
Mechanism
