摘要
目的探析孕妇剖宫产前后凝血四项与产后出血的相关性。方法 85例剖宫产产妇,按照产后出血量情况分为研究组(出血量≥500 ml,45例)与参照组(出血量<500 ml,40例)。对两组产妇剖宫产前后的凝血四项指标进行检测,并展开组间对比。结果产前研究组纤维蛋白原(FIB)低于参照组,凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶原时间-国际标准化比值(PT-INR)均高于参照组,差异均具有统计学意义(P<0.05)。产后研究组FIB低于对照组,TT、APTT、PT、PT-INR均高于参照组,差异均具有统计学意义(P<0.05)。研究组产前FIB、TT、APTT、PT与产后比较差异均无统计学意义(P>0.05);产前PT-INR(1.72±0.50)与产后(1.32±0.13)比较差异具有统计学意义(P<0.05)。结论造成剖宫产产妇产后出血的一大因素即为凝血功能障碍,因此应重视对临产孕妇产前与分娩期间的凝血指标实施监测,以降低产后出血的发生率。
Objective To investigate and analyze the correlation between four items of blood coagulation and postpartum hemorrhage before and after cesarean section in pregnant women. Methods A total of 85 pregnant women with cesarean section were divided by postpartum hemorrhage volume into research group （hemorrhage volume ≥ 500 ml, 45 cases） and control group （hemorrhage volume〈500 ml, 40 cases）. Four items of blood coagulation before and after cesarean section in two groups was detected for comparison. Results Before delivery, the research group had lower fibrinogen （FIB） than the control group, and higher thrombin time （TT）, activated partial thromboplastin time （APTT）, prothrombin time （PT）, prothrombin time-international normalized ratio （PT-INR） than the control group. Their difference was statistically significant （P〈0.05）. After delivery, the research group had lower FIB than the control group, and higher TT, APTT, PT and PT-INR than the control group. Their difference was statistically significant （P〈0.05）. The research group had no statistically significant difference in FIB, TF, APTT, PT before delivery than after delivery （P〉0.05）. There was statistically significant difference in PT-INR before delivery as （1.72 ± 0.50）, comparing with （1.32 ± 0.13） after delivery （P〈0.05）. Conciusion Coagulation dysfunction is a major factor causing postpartum hemorrhage in cesarean section. Therefore, attention should be paid to the monitoring of coagulation indexes during the period of prenatal and postnatal labor in pregnant women, so as to reduce the incidence of,postpartum hemorrhage.
作者
庄凤云
唐宁
ZHUANG Feng-yun TANG Ning(Department of Obstetrics and Gynecology, Guangzhou City Eighth People＇ s Hospital, Guangzhou 510000, China)
出处
《中国实用医药》
2017年第27期25-26,共2页
China Practical Medicine
关键词
剖宫产
凝血
产后出血
Cesarean section
Blood coagulation
Postpartum hemorrhage
