摘要
[目的]探讨活性炭联合营养干预对儿童铅中毒的治疗效果。[方法]选择在某院门诊就诊的儿童铅中毒病例(血铅水平在100~249μg/L范围内,未进行过药物驱铅治疗)77人,按就诊顺序随机分为联合治疗组(39人)和常规治疗组(38人)。常规治疗组给予常规营养干预(钙250 mg/d、锌10 mg/d、维生素C 200 mg/d、维生素B1 5 mg/d,每日睡前一次口服);联合治疗组在常规治疗组治疗基础上加用活性炭片0.9 g/次,餐前口服,3次/日。连续干预治疗30 d,观察两组治疗结束时、治疗结束后第30天的血铅水平。[结果]治疗结束时,联合治疗组儿童血铅水平降至正常范围(98.13μg/L),低于常规治疗组118.10μg/L(P<0.05);治愈25例,治愈率为64.1%,明显高于常规治疗组的28.9%(P<0.01)。治疗结束后第30天,联合治疗组血铅水平持续下降至68.75μg/L,而常规治疗组下降趋势明显变缓,降至108.77μg/L;2组治愈率分别为82.1%和42.1%。[结论]活性炭联合营养干预可明显降低铅中毒儿童的血铅水平。
[Objective] To explore the curative effect of active carbon combined with nutritional intervention against lead poisoning in children.[Methods] A total of 77 lead poisoning children visiting the selected outpatient department in a hospital, whose blood lead levels were in the range of 100-249 μg/L and who did not receive lead expelling drugs, were randomly divided into a combined treatment group（n=39） and a traditional treatment group（n=38）. The traditional treatment group was given routine nutritional intervention（calcium 250 mg/d, zinc 10 mg/d, vitamin C 200 mg/d, and vitamin B1 5 mg/d, oral administration once daily at bedtime）; the combined treatment group was additionally given activated carbon tablet 0.9 g/time before meal, 3 times/d. After continuous intervention treatment for 30 d, the blood lead levels of the two groups were observed at the end of treatment and 30 d later.[Results] At the end of treatment, the combined treatment group＇s average blood lead level dropped to normal range（98.13 μg/L）, lower than that of the traditional treatment group（118.10 μg/L）（P 〈0.05）. Twenty-five cases were cured with a cure rate of 64.1% in the combined treatment group, higher than that of the traditional treatment group（28.9%）（P 〈0.01）. On the 30 th day after the treatment, the average blood lead level of the combined treatment group continued to drop to 68.75 μg/L, while that of the traditional treatment group dropped to 108.77 μg/L with a decrease trend slowing down obviously; the cure rates of the two groups were 82.1% and 42.1%, respectively.[Conclusion] Active carbon combined with nutritional intervention can significantly reduce blood lead level in children with lead poisoning.
出处
《环境与职业医学》
CAS
CSCD
北大核心
2017年第9期808-811,共4页
Journal of Environmental and Occupational Medicine
基金
江西省卫生计生委科技计划(编号:20162005)
关键词
活性炭
营养干预
联合治疗
铅中毒
儿童
active carbon
nutritional intervention
combined treatment
lead poisoning
child
