摘要
目的:探讨喜炎平联合热毒宁注射液对重症手足口病合并脑炎患儿的免疫修复作用。方法:收集临床确证的手足口病合并脑炎患儿72例,随即分为对照组(N=36)和观察组(N=36),观察组除了常规的退烧,补液及补充维生素C之外给予热毒宁注射液(0.6~0.8ml/kg/d)和喜炎平(0.2~0.4ml/kg)静脉滴注,对照组仅给予热毒宁注射液0.6~0.8ml/kg/d静脉滴注,7日一疗程,1次/日,治疗结束后,比较两组疗效,并对治疗前后两组患者的血清免疫球蛋白及补体、外周血T细胞淋巴亚群及血清细胞因子水平进行检测并比较。结果:观察组患儿总有率(97.22%)和痊愈率(75.00%)均明显高于对照组患儿(86.11%和55.56%),副作用发生率显著低于对照组;与对照组治疗后相比,观察组治疗后血清免疫球蛋白IgA、IgG及补体C4水平显著高于对照组治疗后;与对照组治疗后相比,观察组治疗后CD3+T%、CD4^+T%、CD8^+T%及CD4^+/CD8值较对照组治疗后显著升高;观察组治疗后IL-6,IL-10水平显著低于对照组治疗后水平。结论:喜炎平对手足口病合并脑炎患儿免疫损伤具有修复作用,临床疗效确切。
Objective： To discuss the immune repair effect of combination therapy of Xiyanping and Reduning Injection on hand-foot-mouth disease complicated with encephalitis. Methods： 72 cases of patients with hand-foot-mouth disease complicated with encephalitis were randomly divided into two groups： The control group（ N = 36） and observation group（ N = 36）. In addition to the conventional treatment such as reducing the fever,fluid infusion and increasing the vitamin C,patients in the observation group were administered Reduning Injection（ 0. 6 ~ 0.8ml/kg/d） and Xiyanping（ 2g/kg） by intravenous infusion while patients in the control group took only Reduning Injection（ 0. 6 ~ 0. 8ml/kg/d）. The treatment was kept a 7-day course with once a day. When the treatment was finished,the clinical efficacy was evaluated and levels of serum immunoglobulins,complement,lymphocyte subsets of T cells in peripheral blood and serum cytokines were determined. Results： The curable（ 97. 22%） and effective rate（ 75. 00%） were higher than those in the control group（ 86. 11% and 55. 56%）. Compared with the control group after treatment,levels of serum immunoglobulin IgA,IgG and complement C4 were significantly higher than those in the control group,the CD3＋T% 、CD4~＋T% 、CD8~＋T% and CD4~＋/CD8 were significantly higher than those in the control group,levels of IL-6,IL-10 were significantly lower than those in the control group. Conclusion： The Xiyanping makes a contribution on the remediation of immune injury.
出处
《中药药理与临床》
CSCD
北大核心
2017年第4期182-185,共4页
Pharmacology and Clinics of Chinese Materia Medica
关键词
喜炎平注射液
热毒宁注射液
重症手足口病
脑炎
免疫损伤
Xiyanping Injection（喜炎平注射液）
Reduning Injection（热毒宁注射液）
severe hand-foot-mouth disease
encephalitis
immune injure
