摘要
目的探讨首发精神病患者采取齐拉西酮与利培酮治疗的疗效。方法将该院2014年1月—2016年12月接诊的首发精神病患者80例作为研究对象,入选对象家属愿意配合该研究,按照随机数表法进行分组,每组40例。对照组患者采取利培酮治疗,研究组患者采取齐拉西酮治疗,对两组患者临床效果、不良反应进行观察记录,并实施统计学分析。结果两组患者治疗前阳性与阴性症状量表(PANSS)、阳性症状、阴性症状、精神病理评分比较差异无统计学意义[研究组:(75.09±3.45)分、(23.09±2.38)分、(16.78±4.22)分、(39.87±2.18)分,对照组:(75.34±3.62)分、(23.13±2.35)分、(16.56±4.76)分、(39.76±2.44)分](P>0.05),治疗后两组患者均有下降(P<0.05),但治疗后研究组显著低于对照组[研究组:(31.86±4.57)分、(8.11±1.05)分、(8.08±1.23)分、(18.09±2.56)分,对照组:(39.32±2.54)分、(9.68±1.87)分、(9.89±1.72)分、(20.23±2.75)分](P<0.05);两组患者不良反应发生率比较差异无统计学意义(40.00%vs 42.50%,P>0.05),但各有偏重。结论首发精神病患者采取齐拉西酮与利培酮治疗均能取得不错的效果,安全性相当,但齐拉西酮治疗在改善症状上更优,值得借鉴。
Objective To s tudy th e cu ra tive effect of zipras io ne and risp e r id o n e in tre a tm en t of p a t ien ts with f irs t - episode psychosis. Methods 80 cases of p a t ien ts with f i r s t -e p iso d e psychosis adm it ted an d tre a ted in our h ospi tal from January 2014 to December 2016 were selected with the consent of pat ients and their family, the control group and the research group were treated with risper idone and zipras idone, and the cl inical effect and adverse reactions were ob-served and s tat is t ical ly analyzed. Results The differenc es in th e PANSS scores, p ositive symptoms, negative symptoms and mental and pathological scores between the research group and the control group were not s tat is t ical ly s ignif icant, [（75.09±3.45）points, （23.09±2.38）points, （16.78±4.22）points, （39.87±2.18）points vs （75.34±3.62）points, （23.13± 2.35）points, （16.56±4.76）points, （39.76±2.44）points ] （P〉0.05） , af ter treatment, the scores of both groups decreased（P〈 0.05）, but the scores in the research group were obviously lower than those in the control group [ （31.86±4.57）points, （8.11±1.05）points, （8.08±1.23）points, （18.09±2.56）points vs （39.32±2.54）points, （9.68±1.87）points, （9.89±1.72） points,（20.23±2.75）points] （P〈0.05）.and the difference in the incidence rate of adverse reactions was not stat ist ically signif icant （40.00% vs 42.50%, P〉0.05） . Conclusion The effect of zipras io ne an d risp e r id o n e in tre a tm en t of p a tien ts with f i r st -episode psychosis is good, and the safety is s imilar, but the improvement effect of symptoms of zipras idone is bet ter than that of risper idone, which is worth reference.
出处
《系统医学》
2017年第9期12-14,共3页
Systems Medicine
关键词
首发精神病
齐拉西酮
利培酮
阳性与阴性症状量表
F i r s t - e p is o d e psychosis
Z iprasione
R ispe rid o ne
Pos it iv e an d negative symptoms scales
