摘要
目的观察佛山地区老年糖尿病合并心血管病患者的临床特征,并分析其危险因素。方法选取2014年2月至2016年2月间佛山市第一人民医院同济康复医院及佛山市第一人民医院收治的老年2型糖尿病患者1 877例为研究对象,其中600例合并心血管病患者为观察组,1 277例未合并心血管病患者为对照组,比较两组患者的临床资料,并以Logistic多元回归分析方法分析老年2型糖尿病患者合并心血管病的危险因素。结果观察组和对照组患者的糖尿病(DM)病程[(10.3±3.1)年vs(8.9±2.5)年]、吸烟年限[(19.1±6.2)年vs(16.5±6.6)年],体质量指数(BMI)(24.1±1.3 vs 23.3±1.1)比较,观察组均明显长于或大于对照组,差异均有统计学意义(P<0.05);观察组和对照组患者罹患脂肪肝(60.2%vs 54.2%)和脑血管病(56.2%vs 50.4%)的比例比较,观察组均明显高于对照组,差异均有统计学意义(P<0.05);观察组患者的总胆固醇(TC)、甘油三酯(TG)、纤维蛋白原(FIB)、空腹血糖(FBG)、2 h空腹血糖(2 h FBG)及糖化血红蛋白(Hb A1c)均明显高于对照组,高密度脂蛋白(HDL-C)、载脂蛋白A(Apo A)、水平明显低于对照组,差异均有显著统计学意义(P<0.01);Logistic多元回归分析结果显示,糖尿病病程、Hb A1c及吸烟年限是2型糖尿病合并心血管的独立危险因素(P<0.05)。结论 2型糖尿病合并心血管病的发生率高,随着糖尿病病程的延长、Hb A1C控制不良、吸烟年限的延长,其发生心血管病的危险性增加。
Objective To observe the clinical characteristics of diabetes mellitus complicated with cardiovascular disease in Foshan, and to analyze the risk factors. Methods A total of 1 877 patients with type 2 diabetes mellitus（T2DM）, who admitted to Tongji Rehabilitation Hospital of the First People＇s Hospital of Foshan and the First People＇s Hospital of Foshan from February 2014 to February 2016 were selected as the subjects. Among them, 600 patients with cardiovascular disease were the observation group, and 1 277 patients with no cardiovascular disease were included in the control group. The clinical data of the two groups were compared, and logistic regression analysis was used to analyze the risk factors of cardiovascular disease in T2 DM patients. Results The DM course of disease, smoking years,BMI in the observation group were（10.3±3.1） years,（19.1±6.2） years,（24.1±1.3） years, respectively, which were significantly longer or higher than corresponding（8.9±2.5） years（16.5±6.6） years,（23.3±1.1） years in the control group（P〈0.05）. The proportion of fatty liver and cerebrovascular disease of the observation group were respectively 60.2% and56.2%, which were significantly higher than 54.2% and 50.4% of the control group（P〈0.05）. The levels of total cholesterol（TC）, triglyceride（TG）, fibrogen（FIB）, fasting blood glucose（FBG）, 2-h postprandial blood glucose（2 h PBG） and glycosylated hemoglobin（Hb A1c） in the observation group were significantly higher than those in the control group;the levels of high-density lipoprotein（HDL-C） and apolipoprotein A（apo A） were significantly lower than those of the control group（P〈0.01）. Logistic multivariate regression analysis showed that the duration of diabetes, Hb A1 c and duration of smoking were independent risk factors of cardiovascular disease in T2DM（P〈0.05）. Conclusion The incidence of cardiovascular disease in elderly T2 DM is high, and the risk of cardiovascular disease increases with
作者
钟菊
陈劲松
ZHONG Ju CHEN Jin-song(Department of Internal Medicine, Tongji Rehabilitation Hospital of the First People＇s Hospital of Foshan, Foshan 528000, Guangdong, CHINA Department of Endocrinology, the First People＇s Hospital of Foshan, Foshan 528000, Guangdong, CHINA)
出处
《海南医学》
CAS
2017年第16期2599-2601,共3页
Hainan Medical Journal
基金
广东省佛山市卫生和计生局医学科研课题(编号:20170179)
关键词
2型糖尿病
心血管病
缺血性
LOGISTIC分析
Type 2 diabetes mellitus（T2DM）
Cardiovascular disease
Ischemia
Logistic analysis
