摘要
A hollow-core metal-cladding waveguide（HCMW） optofluidic resonator that works based on a free-space coupling technique is designed. An HCMW can excite ultra-high-order modes（UOMs） at the coupled angle, which can be used as an optofluidic resonator to detect alterations of the epidermal growth factor receptor（EGFR）concentration. Theoretical analysis shows that the UOMs excited in the HCMW have a highly sensitive response to the refractive index（RI） variation of the guiding layer. An EGFR solution with a 0.2 ng/mL alteration is detected, and the RI variation caused by the concentration alteration is about 2.5 × 10^（-3）.
A hollow-core metal-cladding waveguide（HCMW） optofluidic resonator that works based on a free-space coupling technique is designed. An HCMW can excite ultra-high-order modes（UOMs） at the coupled angle, which can be used as an optofluidic resonator to detect alterations of the epidermal growth factor receptor（EGFR）concentration. Theoretical analysis shows that the UOMs excited in the HCMW have a highly sensitive response to the refractive index（RI） variation of the guiding layer. An EGFR solution with a 0.2 ng/mL alteration is detected, and the RI variation caused by the concentration alteration is about 2.5 × 10^（-3）.
作者
Jianfeng Shang
Hailang Dai
Yun Zou
Xianfeng Chen
尚剑锋;戴海浪;邹芸;陈险峰(State Key Laboratory of Advanced Optical Communica, tion Systems and Networks, Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China Shanghai Key Laboratory of Crime Science Evidence, Shangha.i Research Institute of Criminal Science and Technology Shanghai 200083, China)
基金
supported by the National Natural Science Foundation of China(No.61235009)
the National Basic Research Programmer of China(No.2013CBA01703)
