摘要
目的 探讨甲状腺乳头状癌患者的临床及病理特点,并分析其与淋巴结转移的相关性.方法 回顾性分析山西大医院2012年1月至2016年12月914例甲状腺乳头状癌患者的临床和病理资料,采用χ2检验及χ2趋势检验分析患者年龄、性别、肿瘤体积、病灶数目及淋巴结转移情况,研究甲状腺乳头状癌发病特点及变化趋势.结果 该院近5年甲状腺乳头状癌病例数呈逐年增加趋势（χ^2=64.009,P=0.001）.年龄≤40岁和〉70岁患者的淋巴结转移率分别为34.9%（84/241）、44.0%（11/25）,均高于年龄41-70岁的患者（15.6%,101/648）,组间差异有统计学意义（χ^2值分别为39.577、14.009,均P=0.000）,呈三相分布特点.年龄≤40岁者,随着年龄递减,淋巴结转移率呈上升趋势（χ^2=10.490,P=0.010）;年龄〉40岁者,随着年龄递增,淋巴结转移率呈上升趋势（χ^2=10.170,P=0.010）.男女性别比为1：2.97,男性患者的淋巴结转移率高于女性患者（χ^2=5.845,P=0.013）.肿瘤直径≤1 cm与〉1 cm的患者有相似的淋巴结转移风险（χ^2=0.070,P=0.610）.多病灶患者的淋巴结转移率高于单病灶患者（χ^2=145.440,P=0.000）.结论 甲状腺乳头状癌的发病率呈上升趋势;年龄≤40岁和〉70岁、男性、肿瘤呈多病灶是发生淋巴结转移的危险因素.
Objective To investigate the clinicopathological characteristics of papillary thyroid carcinoma （PTC）, and analyze their relationship with lymph node metastasis （LNM）. Methods The clinicopathological data of 914 cases of PTC from January 2012 to December 2016 was analyzed retrospectively byχ2 test andχ2 trend test, including age, gender, tumor size, the number of lesions and LNM, in order to illuminate the characteristics of incidence and variation trend of PTC. Results The numbers of PTC cases in Shanxi Dayi Hospital increased year by year in recent 5 years （χ^2=64.009, P=0.001）. The rate of LNM was higher in age of ≤40 years old [34.9 % （84/241）] and 〉70 years old [44.0 % （11/25）] than age 41-70 years old [15.6 % （101/648）] （χ^2 = 39.577 and 14.009, both P= 0.000）. It showed a triphasic pattern, which presented a uptrend with age decreasing in patients ≤ 40 years old （χ^2= 10.490, P= 0.010）, on the contrary, it appeared a rising trend with age increasing in patients〉40 years old （χ^2=10.170, P=0.010）. The sex ratio of male and female was 1：2.97. The rate of LNM for male was higher than female （χ^2=5.845, P=0.013）. There was approximate risk of LNM between tumor diameter ≤1 cm and〉1 cm （χ^2=0.070, P=0.610）. The rate of LNM in the cases of multiple lesions was apparently higher than that in cases of single lesions （χ^2=145.440, P=0.000）. Conclusions The incidence of PTC is on the rise. The risk factors of LNM are age （≤40 years old and〉70 years old）, male and multiple lesions.
作者
李丽
和娟
李雪婷
张振华
赵玉良
Li Li He Juan Li Xueting Zhang Zhenhua Zhao Yuliang(Department of Pathology, Shanxi Dayi Hospital, Taiyuan 030032, Chin)
出处
《肿瘤研究与临床》
CAS
2017年第8期547-550,560,共5页
Cancer Research and Clinic
关键词
甲状腺肿瘤
癌
乳头状
淋巴结转移
危险因素
Thyroid neoplasms
Carcinoma, papillary
Lymphatic metastasis
Risk factors
