摘要
目的探讨替加环素联合头孢哌酮舒巴坦治疗多重耐药鲍曼不动杆菌肺部感染的临床疗效。方法选取医院2015年9月至2016年9月收治的多重耐药鲍曼不动杆菌肺部感染患者82例,按随机数字表法分为两组,各41例。对照组患者采用头孢哌酮舒巴坦治疗,观察组患者在对照组基础上加用替加环素治疗。结果观察组患者治疗总有效率为95.12%,高于对照组的78.05%(P<0.05);细菌清除率为58.54%,高于对照组的34.15%(P<0.05);两组患者白细胞水平无明显差异(P>0.05),但观察组患者C反应蛋白及降钙素原水平均显著低于对照组(P<0.05)。结论替加环素联合头孢哌酮舒巴坦治疗多重耐药鲍曼不动杆菌肺部感染,可明显改善患者炎性反应程度,提高细菌清除率,临床疗效显著,值得临床推广。
Objective To investigate the clinical efficacy of tigecycline combined with sulbactam and cefopcrazone in the treatment of lung infection due to multidrug-resistant Acinetobacter baumannii（ MDR-AB）. Methods Totally 82 patients with lung infection due to MDR-AB admitted to our hospital from September 2015 to September 2016 were divided into two groups according to the random number table method,41 cases in each group. The control group was treated with sulbactam and cefopcrazone, on the basis of this,the observation group was treated with tigecycline. Results The effective rate of the observation group was 95. 12%,which was significantly higher than 78. 05% of the control group（ P〈0. 05）, the bacterial clearance rate of the observation group was 58. 54%, which was significantly higher than 34. 15% of the control group（ P〈0. 05）. After treatment,there was no significant difference in leukocyte levels between the two groups（ P〈0. 05）, while the C-reactive protein and procalcitonin in the observation group were significantly lower than those in the control group（ P〈0. 05）. Conclusion Tigecycline combined with sulbactam and cefopcrazone in the treatment of lung infection due to MDR-AB can obviously improve the inflammatory reaction degree of patients and improve the bacterial clearance rate,and has remarkable clinical curative effect,it is worthy of clinical promotion.
作者
罗青林
刘勇
柏合
赵龙
Luo Qinglin Liu Yong Bo He Zhao Long(Department of Pediatrics, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, China 157011 Medical Research Center, Mudanfiang Medical University, Mudanjiang, Heilongjiang, China 157011)
出处
《中国药业》
CAS
2017年第17期34-36,共3页
China Pharmaceuticals
关键词
替加环素
头孢哌酮舒巴坦
多重耐药鲍曼不动杆菌
肺部感染
tigecycline
sulbactam and cefopcrazone
multidrug-resistant Acinetobacter baumannii
lung infection
