摘要
为了建立费休氏法测定头孢拉定胶囊水分的不确定度评定,根据《测量不确定度评定与表示》(JJF1059-1999),分析不确定度的来源,通过建立数学模型,对水分测定过程中各影响因素进行分析评估,计算各变量的不确定度,合成不确定度,得出水分测定的扩展不确定度为0.28%(k=2),该方法适用于费休氏法测定头孢拉定胶囊水分的不确定度评定。
To establish a method of uncertainty evaluation for the water determination of cefradine capsules by Karl Fisher＇s method,according to＂the evaluation and expression of uncertainty in measurement ＂（ JJF1059-1999）,the source of the uncertainty analysis,through the establishment of mathematical model,analyze the influence factors in the process of moisture determination. By calculating the uncertainty of each variable,synthetic uncertainty,and expanded uncertainty for the determination of moisture content of 0. 28%（ k = 2）. This method is applicable to Karl Fisher＇s determination to pull on cefradine capsules moisture uncertainty evaluation.
作者
高娟
刘燕
亢玉红
高霞
王彦娥
GAO Juan LIU Yan KANG Yu-hong GAO Xia WANG Yan-e(Yulin Institute for Drug Control, Yulin 719000, China Yulin University School of Chemistry and Chemical Engineering, Yulin 719000, China)
出处
《药物生物技术》
CAS
2017年第4期331-333,共3页
Pharmaceutical Biotechnology
关键词
费休氏法
不确定度
评定
头孢拉定
水分测定
Karl Fisher＇s method
Uncertainty
Evaluation
Cefradine
Water determination
