摘要
目的观察大柴胡汤加减治疗晚期消化道肿瘤癌性发热的有效性并探讨其机制。方法选取中晚期消化道肿瘤(胰腺、胆囊、胃癌等)癌性发热患者60例,其中治疗组30例患者给予大柴胡汤加减口服,对照组给予物理降温或地塞米松2 mg肌肉注射,两组均进行7 d治疗。结果治疗组30例患者中显效16例,有效8例,无效6例,总有效率80.00%,对照组30例患者中治疗显效6例,有效14例,无效10例,总有效率66.67%,治疗组优于对照组(P<0.05);两组在治疗前后KPS评分提高率方面差异有统计学意义(P<0.05);两组在治疗焦虑方面差异明显(P<0.05);且两者不良反应恶心、呕吐等方面对比未见明显变化(P>0.05)。结论中晚期消化道肿瘤癌性发热者,大柴胡汤退热效果显著。
Objective： To observe the efficacy of Dachaihu Decoction on advanced gastrointestinal cancer fever,and explore its mechanism. Methods： 60 cases of cancer fever with advanced digestive cancer（pancreas,gallbladder,stomach cancer） were selected. 30 cases in treatment group were given Dachaihu Decoction orally;the control group was given physical cooling or intramuscular injection of dexamethasone 2 mg. Two groups were treated for 7 days. Results： In 30 cases of the treatment group,16 cases were markedly effective,8 cases effective,6 cases ineffective,and the total effective rate was 80.00%. In 30 cases of the control group,6 cases were markedly effective,14 cases effective,10 cases ineffective,and the total effective rate was 66.67%. The treatment group was better than the control group（P 0.05）. Before and after treatment,KPS score increased in both groups,with statistical significance（P 0.05）. In the treatment of anxiety（SAS）,the comparison between the two groups had statistical significance（P 0.05）. There was no significant change in the adverse reactions such as nausea and vomiting（P 0.05）. Conclusion： In advanced gastrointestinal cancer fever,the antipyretic effect of Dachaihu Decoction was remarkable.
出处
《中国中医急症》
2017年第9期1636-1638,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
陕西省科技统筹创新工程计划项目(2016KTCL03-16)
关键词
癌性发热
大柴胡汤
中医
消化道肿瘤
焦虑
Cancer fever
Dachaihu Decoction
TCM
Gastrointestinal cancer
Anxiety
