摘要
目的:通过观察痛风方治疗湿热夹瘀型痛风患者的临床疗效,评价其有效性及安全性。方法:采用随机平行对照方法,将120例患者分为对照组和观察组,各60例,对照组给予口服塞来昔布胶囊0.2 g/次,2次/d。观察组在对照组基础上加服痛风方,1剂/d,两组患者疗程均为2周。分别记录治疗前和治疗后患者休息时关节肿痛分数,关节压痛分数,关节肿胀分数,总分数,关节肿痛指数,关节功能分级,C反应蛋白(CRP),血沉(ESR),D-二聚体(DD-i),血尿酸(UA)水平及生活质量评分(SF-36)的改变,并记录不良反应发生情况。结果:经治疗2周后,观察组临床有效率为87.27%,高于对照组的66.04%(χ2=7.536,P<0.05);观察组休息时关节肿痛分数,关节压痛分数,总分数,关节功能评分,CRP,ESR,DD-i,UA均低于对照组(P<0.05);观察组关节肿痛指数,生活质量SF-36评分均高于对照组(P<0.05)。两组患者不良事件发生率无统计学差异。结论:痛风方联合塞来昔布治疗湿热夹瘀型痛风性关节炎疗效确切,抗炎作用强,安全性好,且能降低血尿酸水平而不诱发痛风急性发作。
Objective： To observe the effect of Tongfeng decoction in treating gout patients with moist heat and blood stasis syndrome treated,in order to evaluate the efficacy and safety of Tongfeng decoction in treating acute gout. Method： With a randomized,parallel-controlled approach,one hundred and twenty gout patients were divided into control group and observation group. Patients in control group were treated with celecoxib 0. 2 g,twice a day. Patients in observation group were treated with celecoxib 0. 2 g,twice a day,and combined with Tongfeng decoction,one dose a day. Both groups received therapy for 2 weeks. The changes in score of joint gall in rest,score of joint tenderness,score of joint swollen,gross score,index of joint gall,score of joint function,serum levels of C-reactive protein,erythrocyte sedimentation rate,D-dimer and uric acid,life quality（ SF-36）,and adverse reactions were recorded. Result： After treating for two weeks,the total effective rate in observation group was 87. 27%,which was superior to 66. 04% in control group（ χ~2= 7. 536,P〈0. 05）. The score of joint gall in rest,score of joint tenderness,score of joint swollen,gross score,score of joint function,serum levels of Creactive protein,erythrocyte sedimentation rate,D-dimer and uric acid in observation group were lower than those in control group（ P〈0. 05）. Index of joint gall and life quality in observation group were higher than those in control group（ P〈0. 05）. The rate of adverse reactions between control group and observation group had no statistical difference. Conclusion： Tongfeng decoction combined with celecoxib shows a positive effect in treating gout patients with moist heat and blood stasis syndrome. The Tongfeng decoction has strong anti-inflammatory activity and security. It can reduce the serum level of uric acid,without inducing acute attack.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第18期186-190,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81573930)
关键词
痛风
痛风方
尿酸
瘀血
痰浊
gout
Tongfeng decoction
uric acid
blood stasis
phlegm
