摘要
目的探讨丁苯酞联合前列地尔治疗缺血性脑卒中的临床疗效及对超敏C反应蛋白(hs-CRP)的影响。方法收集2014年1月—2016年3月河南科技大学第一附属医院收治的85例缺血性脑卒中患者,随机分为对照组(43例)和观察组(42例)。两组患者均接受常规治疗,对照组在常规治疗基础上给予注射用前列地尔10μg静脉推注,1次/d。观察组在对照组的基础上加用丁苯酞胶囊0.2 g/次,3次/d,顿服。两组患者均连续治疗14 d。观察比较两组治疗前后的神经功能缺损评分(NIHSS)、日常生活自理能力量表(ADL)、hs-CRP、凝血功能指标的变化,以及临床疗效。结果治疗14 d后,两组的NIHSS、ADL评分、hs-CRP水平均有明显改善,同组治疗前后比较差异有统计学意义(P<0.05)。观察组的NIHSS评分显著低于对照组,ADL评分明显高于对照组,且hs-CRP水平明显低于对照组,组间比较差异有统计学意义(P<0.05)。治疗前,两组的凝血功能指标比较差异无统计学意义。治疗14 d后,两组的凝血酶原时间(PT)、D-二聚体(DD)及纤维蛋白酶原(FIB)均较治疗前有明显改善,同组治疗前后比较差异有统计学意义(P<0.05);且观察组的PT显著高于对照组,DD和FIB明显低于对照组,组间比较差异有统计学意义(P<0.05)。此外,观察组患者的临床治疗有效率(90.5%)显著高于对照组(72.1%),差异具有统计学意义(P<0.05)。结论相较于前列地尔单一用药,联合丁苯酞治疗能更好改善缺血性脑卒中患者的神经功能、日常生活能力及凝血功能,抑制hs-CRP水平,临床疗效显著。
Objective To investigate the clinical efficacy of alprostadil combined with butylphthalide on patients with acute ischemic stroke and its effect on hs-CRP. Methods Eighty-five patients with acute ischemic stroke admitted into our hospital were divided randomly into observation group （n = 42） and control group （n = 43）. Patients in control group were treated with alprostadil, and those in observation group were treated with alprostadil combined with butylphthalide. The neurologic impairment score （NIHSS）, ADL score, hs-CRP, coagulation function, and clinical efficacy in the two groups were observed and compared. Results After 14 days of treatment, the NIHSS and ADL score in both groups were improved, and NIHSS in observation group were much lower than control group, ADL were much higher, and hs-CRP were markedly lower than that of control （P 〈 0.05）. And the coagulation function indexes in both groups were obvious lowered, and DD and FIB in observation group were conspicuously lower than those in control group, and PT were much higher （P 〈 0.05）. In addition, observation group with effective rate of 90.5% were significantly higher than that of control group with 72.1% （P 〈 0.05）. Conclusion Compared with only alprostadil treatment, alprostadil combined with butylphthalide had a better capability of treating patients with acute ischemic stroke by improving coagulation function and neurologic function, and inhibiting levels of hs-CRP.
出处
《药物评价研究》
CAS
2017年第7期975-978,共4页
Drug Evaluation Research
关键词
缺血性脑卒中
前列地尔
丁苯酞
疗效
超敏C反应蛋白
ischemic stroke
alprostadil
butylphthalide
clinical efficacy
high sensitive C-reactive protein
