摘要
创伤性颅脑损伤后出现的腺垂体功能减退可表现非特异性的神经精神症状，在重型颅脑损伤、慢性重复颅脑损伤、使用镇静止痛药及合并蛛网膜下腔出血、颅底骨折、脑疝的患者中容易发生。其可能的发病机制包括血管假说、缺血／缺氧性损伤、遗传易感性、自身免疫、炎性反应等，检测基础激素水平或激素刺激试验有助于确诊。继发肾上腺皮质功能减退者应给予激素替代治疗。
Hypopituitarism after traumatic brain injury （TBI） may result in non-specific neuropsychiatric symptoms, which is commonly occurred in patients suffering from severe traumatic injury, chronic repetitive brain injury, and patients administrated with pain-killer and complicated with subarachnoid hemorrhage, skull base fracture and cerebral hernia. The conceivable pathogenesis of hypopituitarism includes vascular hypothesis, ischemic/anoxia injury, genetic predisposition, autoimmunity and inflammatory response. Detection of basal hormone level or test of hormone stimulation is conducive to the diagnosis of hypopituitarism. Patients with secondary adrenal insufficiency should be given hormone replacement therapy.
出处
《中华神经医学杂志》
CSCD
北大核心
2017年第9期962-965,共4页
Chinese Journal of Neuromedicine
基金
南京军区福州总医院创新团队基金（2014CXTD07）
