摘要
目的研究非甾体抗炎药物萘丁美酮的新合成路线。方法以2-甲基-6萘酚为起始原料,经过甲基化、氯化、烷基化和脱羧反应,合成目标产物萘丁美酮。结果在最佳实验条件下目标产物的总收率达86.5%,其中间产物和目标产物的化学结构均经1H NMR、13C NMR和MS等方法进行了表征。结论该合成路线具有操作简单,收率高等优点。
Objective To study the new synthetic route of the nonsteroidal anti-inflammatory drugs naphthalene. Methods The synthesis of nabumetone was accomplished using 2-methyl-6-naphthol as the starting material, by a route involving reactions of methylation, chlorination, alkylation and decarboxylation. Results The total yield of the target product was 86.5% under the optimum experimental characterized by 1H NMR, 13C NMR and MS. Conclusion and a high overall yield. conditions. The chemical structure of the final product was The synthetic route has the advantages of simple operations
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2017年第9期780-783,共4页
Chinese Journal of Antibiotics
基金
重庆市社会民生科技创新专项(No.cstc2015shmszx80060)
活性物质生物技术教育部工程研究中心开放基金项目(No.20150408)
关键词
萘丁美酮
表征
目标产物
Nabumetone
Characterized
Target product
